Evidence map›Paper›PMID 27274817›Full record

ReviewClinical kidney journal2016

Omics databases on kidney disease: where they can be found and how to benefit from them.

Theofilos Papadopoulos, Magdalena Krochmal, Katryna Cisek, Marco Fernandes, Holger Husi, Robert Stevens, Jean-Loup Bascands, Joost P Schanstra, Julie Klein

Abstract readReview
In one paragraph

Review in Clinical kidney journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Implications of Sphingolipid Metabolites in Kidney Diseases.International journal of molecular sciences · 2022
    Review
  7. Review
  8. Article
  9. Review
  10. Big Data in Nephrology.Nature reviews. Nephrology · 2021
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Frontiers in pharmacology · 2019
    Review
  17. Article
  18. Review
  19. The systemic nature of CKD.Nature reviews. Nephrology · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Theofilos PapadopoulosInstitut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease, Toulouse, France; Université Toulouse III Paul-Sabatier, Toulouse, France.
Magdalena KrochmalBiotechnology Division, Biomedical Research Foundation Academy of Athens, Athens, Greece; Institute for Molecular Cardiovascular Research, Universitätsklinikum RWTH Aachen, Aachen, Germany.
Katryna CisekMosaiques Diagnostics GmbH , Hannover , Germany.
Marco FernandesBHF Glasgow Cardiovascular Research Centre , University of Glasgow , Glasgow , UK.
Holger HusiBHF Glasgow Cardiovascular Research Centre , University of Glasgow , Glasgow , UK.
Robert StevensSchool of Computer Science , University of Manchester , Manchester , UK.
Jean-Loup BascandsInstitut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease, Toulouse, France; Université Toulouse III Paul-Sabatier, Toulouse, France.
Joost P SchanstraInstitut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease, Toulouse, France; Université Toulouse III Paul-Sabatier, Toulouse, France.
Julie KleinInstitut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease, Toulouse, France; Université Toulouse III Paul-Sabatier, Toulouse, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the recent decades, the evolution of omics technologies has led to advances in all biological fields, creating a demand for effective storage, management and exchange of rapidly generated data and research discoveries. To address this need, the development of databases of experimental outputs has become a common part of scientific practice in order to serve as knowledge sources and data-sharing platforms, providing information about genes, transcripts, proteins or metabolites. In this review, we present omics databases available currently, with a special focus on their application in kidney research and possibly in clinical practice. Databases are divided into two categories: general databases with a broad information scope and kidney-specific databases distinctively concentrated on kidney pathologies. In research, databases can be used as a rich source of information about pathophysiological mechanisms and molecular targets. In the future, databases will support clinicians with their decisions, providing better and faster diagnoses and setting the direction towards more preventive, personalized medicine. We also provide a test case demonstrating the potential of biological databases in comparing multi-omics datasets and generating new hypotheses to answer a critical and common diagnostic problem in nephrology practice. In the future, employment of databases combined with data integration and data mining should provide powerful insights into unlocking the mysteries of kidney disease, leading to a potential impact on pharmacological intervention and therapeutic disease management.

Indexed as

bioinformaticsdata integrationkidney diseaseomics databasessystem biology

Identifiers

PMID27274817
PMCPMC4886900

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.