ArticleOxidative medicine and cellular longevity2016
Antidiabetic and Antinephritic Activities of Aqueous Extract of Cordyceps militaris Fruit Body in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats.
Article in Oxidative medicine and cellular longevity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Integrative Roles of Functional Foods, Microbiotics, Nutrigenetics, and Nutrigenomics in Managing Type 2 Diabetes and Obesity.Nutrients · 2025Pooled it
- Potential Therapeutic Effects of Natural Plant Compounds in Kidney Disease.Molecules (Basel, Switzerland) · 2021Pooled it
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- The Potential of Naturally Derived Compounds for Treating Chronic Kidney Disease: A Review of Autophagy and Cellular Senescence.International journal of molecular sciences · 2024Review
- A Novel In Vivo Method UsingPharmaceuticals (Basel, Switzerland) · 2024Article
- The Anti-Diabetic Effect of Non-Starch Polysaccharides Extracted from Wheat Beer on Diet/STZ-Induced Diabetic Mice.Foods (Basel, Switzerland) · 2024Article
- Light-Exposed Metabolic Responses ofBiology · 2024Article
- Impacts of selenium enrichment on nutritive value and obesity prevention ofFood chemistry: X · 2023Article
- Polysaccharides from natural resource: ameliorate type 2 diabetes mellitus via regulation of oxidative stress network.Frontiers in pharmacology · 2023Review
- Potential Therapeutic Strategies for Renal Fibrosis: Cordyceps and Related Products.Frontiers in pharmacology · 2022Review
- The effect of cordycepin on brain oxidative stress and protein expression in streptozotocin-induced diabetic mice.The Journal of veterinary medical science · 2021Article
- Antidiabetic and Nephroprotective Effects of Polysaccharide Extract from the SeaweedDiabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Assessment of antidiabetic potential and phytochemical profiling of Rhazya stricta root extracts.BMC complementary medicine and therapies · 2020Article
- Simultaneous Quantification of Adenosine and Deoxyadenosine Isomers in Foods with High Sensitivity.Analytical methods : advancing methods and applications · 2019Article
- Glucose-lowering and hypolipidemic activities of polysaccharides from Cordyceps taii in streptozotocin-induced diabetic mice.BMC complementary and alternative medicine · 2019Article
- Anti-Diabetic Effects and Mechanisms of Dietary Polysaccharides.Molecules (Basel, Switzerland) · 2019Review
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10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cordyceps militaris has long been used as a crude drug and folk tonic food in East Asia. The present study aims to evaluate the antidiabetic and antinephritic effects of the aqueous extract of the Cordyceps militaris fruit body (CM) in diet-streptozotocin- (STZ-) induced diabetic rats. During four weeks of continuous oral administration of CM at doses of 0.5, 1.0, and 2.0 g/kg and metformin at 100 mg/kg, the fasting blood glucose and bodyweight of each rat were monitored. Hypoglycemic effects of CM on diabetic rats were indicated by decreases in plasma glucose, food and water intake, and urine output. The hypolipidemic activity of CM was confirmed by the normalization of total cholesterol, triglycerides, and low- and high-density lipoprotein cholesterol in diabetic rats. Inhibitory effects on albuminuria, creatinine, urea nitrogen, and n-acetyl-β-d-glucosaminidase verified CM's renal protective activity in diabetic rats. Furthermore, CM exerted beneficial modulation of inflammatory factors and oxidative enzymes. Compared with untreated diabetic rats, CM decreased the expression of phosphor-AKT and phosphor-GSK-3β in the kidneys. Altogether, via attenuating oxidative stress, CM displayed antidiabetic and antinephritic activities in diet-STZ-induced diabetic rats.
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