ArticleThe World Allergy Organization journal2016
World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Vitamin D.
Article in The World Allergy Organization journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Vitamin D supplementation in pregnant or breastfeeding women or young children for preventing asthma.The Cochrane database of systematic reviews · 2025Pooled it
- Vitamin D Supplementation and Allergic Rhinitis: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Acceptance of food allergic children in Japanese childcare facilities.Asia Pacific allergy · 2024Article
- Environmental Interventions for Preventing Atopic Diseases.Current allergy and asthma reports · 2024Review
- Food Allergy Risk: A Comprehensive Review of Maternal Interventions for Food Allergy Prevention.Nutrients · 2024Review
- Trends of vitamin D in asthma in the pediatric population for two decades: a systematic review.Clinical and experimental pediatrics · 2023Article
- Further Insights into the Gut Microbiota of Cow's Milk Allergic Infants: Analysis of Microbial Functionality and Its Correlation with Three Fecal Biomarkers.International journal of molecular sciences · 2023Article
- A systematic review of quality and consistency of clinical practice guidelines on the primary prevention of food allergy and atopic dermatitis.The World Allergy Organization journal · 2023Article
- Early Oral Nutritional Supplements in the Prevention of Wheezing, Asthma, and Respiratory Infections.Frontiers in pediatrics · 2022Review
- How to write a guideline: a proposal for a manuscript template that supports the creation of trustworthy guidelines.Blood advances · 2021Article
- Association of vitamin D gene polymorphisms in children with asthma - A systematic review.Heliyon · 2020Review
- Halting the March: Primary Prevention of Atopic Dermatitis and Food Allergies.The journal of allergy and clinical immunology. In practice · 2020Article
- Prebiotics: Mechanisms and Preventive Effects in Allergy.Nutrients · 2019Review
- Primary Prevention of Food Allergy.Current allergy and asthma reports · 2019Review
- Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians.Italian journal of pediatrics · 2018Review
- Microbial Delivery Vehicles for Allergens and Allergen-Derived Peptides in Immunotherapy of Allergic Diseases.Frontiers in microbiology · 2018Review
- Human Milk and Allergic Diseases: An Unsolved Puzzle.Nutrients · 2017Review
- Primary Prevention of Food Allergy.Current allergy and asthma reports · 2017Review
- Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years.Clinical therapeutics · 2017Review
- National clinical practice guidelines for food allergy and anaphylaxis: an international assessment.Clinical and translational allergy · 2017Article
Corrections and comments
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Authors and funding
27 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of allergic diseases is approximately 10 % in infants whose parents and siblings do not have allergic diseases and 20-30 % in those with an allergic first-degree relative. Vitamin D is involved in the regulation of the immune system and it may play a role in the development, severity and course of asthma and other allergic diseases.
objectiveThe World Allergy Organization (WAO) convened a guideline panel to develop evidence-based recommendations addressing the use of vitamin D in primary prevention of allergic diseases.
methodsOur WAO guideline panel identified the most relevant clinical questions and performed a systematic review of randomized controlled trials and non-randomized studies (NRS), specifically cohort and case-control studies, of vitamin D supplementation for the prevention of allergic diseases. We also reviewed the evidence about values and preferences, and resource requirements (up to January 2015, with an update on January 30, 2016). We followed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to develop recommendations.
resultsHaving reviewed the currently available evidence, the WAO guideline panel found no support for the hypothesis that vitamin D supplementation reduces the risk of developing allergic diseases in children. The WAO guideline panel suggest not using vitamin D in pregnant women, breastfeeding mothers, or healthy term infants as a means of preventing the development of allergic diseases. This recommendation does not apply to those mothers and infants who have other indications for prophylactic or therapeutic use of vitamin D. The panel's recommendations are conditional and supported by very low certainty evidence.
conclusionsWAO recommendations about vitamin D supplementation for the prevention of allergic diseases support parents, clinicians and other health care professionals in their decisions whether or not to use vitamin D in preventing allergic diseases in healthy, term infants.
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Registered trials
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