ReviewNeuropsychiatric disease and treatment2016
Clinical features, comorbidity, and cognitive impairment in elderly bipolar patients.
Review in Neuropsychiatric disease and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- History of Bipolar Disorder and the Risk of Dementia: A Systematic Review and Meta-Analysis.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Pooled it
- Bipolar Disorder in Older Adults: A Comprehensive Overview of Pharmacotherapy Patterns and Clinical Considerations.Drugs & aging · 2026Review
- Comorbidity of undiagnosed mood symptoms with dementia risk in multi-regional multi-ethnic adults: evidence from epidemiological findings and plasma metabolites.Epidemiology and psychiatric sciences · 2025Article
- Influence of BPPV and Meniere's Disease on Cognitive Abilities: A Questionnaire-Based Study.Journal of otology · 2024Article
- A systematic review of psychosocial functioning and quality of life in older people with bipolar disorder.Journal of affective disorders reports · 2022Review
- Developing a recovery-focused therapy for older people with bipolar disorder: a qualitative focus group study.BMJ open · 2021Article
- Cognitive Trajectories in Comorbid Dementia With Schizophrenia or Bipolar Disorder: The South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLaM BRC) Case Register.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Article
- The Heterogeneity of Longitudinal Cognitive Decline in Euthymic Bipolar I Disorder With Clinical Characteristics and Functional Outcomes.Frontiers in psychiatry · 2021Article
- Increased Risk of Dementia Among Veterans With Bipolar Disorder or Schizophrenia Receiving Care in the VA Health System.Psychiatric services (Washington, D.C.) · 2020Article
- Influence of cognitive impairment on cardiac mortality after percutaneous coronary intervention in very elderly patients: a retrospective observational study.Journal of geriatric cardiology : JGC · 2019Article
- A review on shared clinical and molecular mechanisms between bipolar disorder and frontotemporal dementia.Progress in neuro-psychopharmacology & biological psychiatry · 2019Review
- Update on the Epidemiology, Diagnosis, and Treatment of Mania in Older-Age Bipolar Disorder.Current psychiatry reports · 2017Review
- Association of Alzhemier's disease with hepatitis C among patients with bipolar disorder.PloS one · 2017Article
- Executive Function Is Selectively Impaired in Old Age Bipolar Depression.Frontiers in psychology · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionData specific to late-life bipolar disorder (BD) are limited. Current research is sparse and present guidelines are not adapted to this group of patients.
objectivesWe present a literature review on clinical characteristics, comorbidities, and cognitive impairment in patients with late-life BD. This review discusses common comorbidities that affect BD elders and how aging might affect cognition and treatment.
methodsEligible studies were identified in MedLine by the Medical Subject Headings terms "bipolar disorder" and "aged". We only included original research reports published in English between 2012 and 2015.
resultsFrom 414 articles extracted, 16 studies were included in the review. Cardiovascular and respiratory conditions, type II diabetes, and endocrinological abnormalities were observed as highly prevalent. BD is associated with a high suicide risk. Bipolar elderly had an increased risk of dementia and performed worse on cognitive screening tests compared to age-matched controls across different levels of cognition. Despite high rates of medical comorbidity among bipolar elderly, a systematic under-recognition and undertreatment of cardiovascular disease have been suggested.
conclusionThere was a high burden of physical comorbidities and cognitive impairment in late-life BD. Bipolar elderly might be under-recorded and undertreated in primary medical care, indicating that this group needs an adapted clinical assessment and specific clinical guidelines need to be established.
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