ArticleProceedings of the National Academy of Sciences of the United States of America2016
Leucokinin mimetic elicits aversive behavior in mosquito Aedes aegypti (L.) and inhibits the sugar taste neuron.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Small molecules as arthropod kinin receptor antagonists, feeding modulators, or novel mosquitocidal agents.Pest management science · 2026Article
- Acaricidal activity of small molecule antagonists of the tick kinin receptor against Rhipicephalus microplus acaricide-susceptible and resistant strains.Pest management science · 2026Article
- Design, Synthesis, and Aphicidal Activity of Novel Insect Neuropeptide Kinin Receptor Antagonists, Targeting the SerJournal of agricultural and food chemistry · 2025Article
- Adaptive genomic signatures of globally invasive populations of the yellow fever mosquito Aedes aegypti.Nature ecology & evolution · 2025Article
- The GPCR A35 regulates fecundity ofFrontiers in insect science · 2025Article
- De novo transcriptome assembly and differential gene expression analysis in different developmental stages of Agriotes sputator (click beetle).Scientific reports · 2024Article
- A fluorescently-tagged tick kinin neuropeptide triggers peristalsis and labels tick midgut muscles.Scientific reports · 2024Article
- Automated analysis of feeding behaviors of females of the mosquito Aedes aegypti using a modified flyPAD system.Scientific reports · 2023Article
- Kdr genotyping (V1016I, F1534C) of the Nav channel of Aedes aegypti (L.) mosquito populations in Harris County (Houston), Texas, USA, after Permanone 31-66 field tests and its influence on probability of survival.PLoS neglected tropical diseases · 2021Article
- Insects as a New Complex Model in Hormonal Basis of Obesity.International journal of molecular sciences · 2021Review
- G-Protein Coupled Receptors (GPCRs) in Insects-A Potential Target for New Insecticide Development.Molecules (Basel, Switzerland) · 2021Review
- G-Protein Coupled Receptors (GPCRs): Signaling Pathways, Characterization, and Functions in Insect Physiology and Toxicology.International journal of molecular sciences · 2021Review
- Leucokinin and Associated Neuropeptides Regulate Multiple Aspects of Physiology and Behavior inInternational journal of molecular sciences · 2021Review
- Leucokinins: Multifunctional Neuropeptides and Hormones in Insects and Other Invertebrates.International journal of molecular sciences · 2021Review
- Functional Identification and Characterization of Leucokinin and Its Receptor in the Fall Webworm,Frontiers in physiology · 2021Article
- Drosophila Aversive Behavior toward Erwinia carotovora carotovora Is Mediated by Bitter Neurons and Leukokinin.iScience · 2020Article
- Transcriptomics supports local sensory regulation in the antenna of the kissing-bug Rhodnius prolixus.BMC genomics · 2020Article
- Engineered action at a distance: Blood-meal-inducible paralysis in Aedes aegypti.PLoS neglected tropical diseases · 2019Article
- The Cattle Fever Tick,Frontiers in physiology · 2019Article
- G protein-coupled receptors in arthropod vectors: omics and pharmacological approaches to elucidate ligand-receptor interactions and novel organismal functions.Current opinion in insect science · 2018Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insect kinins (leucokinins) are multifunctional peptides acting as neurohormones and neurotransmitters. In females of the mosquito vector Aedes aegypti (L.), aedeskinins are known to stimulate fluid secretion from the renal organs (Malpighian tubules) and hindgut contractions by activating a G protein-coupled kinin receptor designated "Aedae-KR." We used protease-resistant kinin analogs 1728, 1729, and 1460 to evaluate their effects on sucrose perception and feeding behavior. In no-choice feeding bioassays (capillary feeder and plate assays), the analog 1728, which contains α-amino isobutyric acid, inhibited females from feeding on sucrose. It further induced quick fly-away or walk-away behavior following contact with the tarsi and the mouthparts. Electrophysiological recordings from single long labellar sensilla of the proboscis demonstrated that mixing the analog 1728 at 1 mM with sucrose almost completely inhibited the detection of sucrose. Aedae-KR was immunolocalized in contact chemosensory neurons in prothoracic tarsi and in sensory neurons and accessory cells of long labellar sensilla in the distal labellum. Silencing Aedae-KR by RNAi significantly reduced gene expression and eliminated the feeding-aversion behavior resulting from contact with the analog 1728, thus directly implicating the Aedae-KR in the aversion response. To our knowledge, this is the first report that kinin analogs modulate sucrose perception in any insect. The aversion to feeding elicited by analog 1728 suggests that synthetic molecules targeting the mosquito Aedae-KR in the labellum and tarsi should be investigated for the potential to discover novel feeding deterrents of mosquito vectors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.