ArticleArthritis care & research2017
Dietary Fat Intake and Radiographic Progression of Knee Osteoarthritis: Data From the Osteoarthritis Initiative.
Article in Arthritis care & research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Using Mendelian randomization analyses in osteoarthritis: state of art and future perspectives.Annals of medicine · 2025Pooled it
- Pooled it
- An anti-inflammatory diet intervention for knee osteoarthritis: a feasibility study.BMC musculoskeletal disorders · 2022Trial
- Multifactorial contributors to knee osteoarthritis identified by Machine Learning and Bayesian network analysis: A cross-sectional study of the Iwaki Health Promotion Project.Osteoarthritis and cartilage open · 2026Article
- Evolving Strategies for Knee Osteoarthritis: A Narrative Review of Integrated Rehabilitation, Pharmacologic, and Joint-Preserving Interventions.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Metabolomic Signatures of Dietary Patterns and Incident Radiographic Knee Osteoarthritis: A Case-Cohort Study From the Osteoarthritis Initiative.The Journal of rheumatology · 2026Article
- Modulation of inflammatory pathways by omega-3 fatty acids in knee joint health for the management of post-traumatic osteoarthritis: a review.Arthritis research & therapy · 2026Review
- Association between Diet Quality and Knee Osteoarthritis: Insights from the Korea National Health and Nutrition Examination Survey 2013.Journal of bone metabolism · 2025Article
- Eicosapentaenoic acid restores inflammation-induced changes in chondrocyte mechanics by suppressing the NF-κB p65/CD44 signaling pathway and attenuates osteoarthritis.Experimental & molecular medicine · 2025Article
- Knee osteoarthritis rehabilitation: an integrated framework of exercise, nutrition, biomechanics, and physical therapist guidance-a narrative review.European journal of medical research · 2025Review
- Diet in Knee Osteoarthritis-Myths and Facts.Nutrients · 2025Review
- Association of unsaturated fatty acid intake with risk of all-cause death in patients with osteoarthritis.Frontiers in nutrition · 2025Article
- The role of metabolites in the progression of osteoarthritis: Mechanisms and advances in therapy.Journal of orthopaedic translation · 2025Review
- Review
- Fatty Acid Intake and Polyunsaturated Fatty Acid Biomarkers and Risk of Total Knee or Hip Arthroplasty Among Older Women in the Women's Health Initiative.Arthritis care & research · 2024Article
- Omega-3 Supplementation and Its Effects on Osteoarthritis.Nutrients · 2024Review
- Beneficial Impact of Eicosapentaenoic Acid on the Adverse Effects Induced by Palmitate and Hyperglycemia on Healthy Rat Chondrocyte.International journal of molecular sciences · 2024Article
- Causal relationship between diet and knee osteoarthritis: A Mendelian randomization analysis.PloS one · 2024Article
- Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms.Bone research · 2023Review
- The Role of Polyunsaturated Fatty Acids in Osteoarthritis: Insights from a Mendelian Randomization Study.Nutrients · 2023Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveFew studies have investigated the role of dietary factors on knee osteoarthritis (OA) progression. We examined the prospective association of dietary fat intake with radiographic progression of knee OA.
methodsIn the Osteoarthritis Initiative, 2,092 participants with radiographic knee OA and having baseline dietary data were followed at yearly intervals up to 48 months. Dietary intakes of fatty acids were assessed with the Block Brief Food Frequency Questionnaire. To evaluate radiographic progression of knee OA, we used quantitative joint space width (JSW) between the medial femur and tibia of the knee based on fixed-flexion posteroanterior radiographs. Linear mixed models for repeated measures were used to test the association between dietary fat and JSW loss over time.
resultsWe observed significant positive relationships of total fat and saturated fatty acids (SFA) intakes with JSW loss. With increasing quartiles of total fat intake, JSW decreases over 48 months were 0.26 mm, 0.27 mm, 0.31 mm and 0.35 mm, respectively (P = 0.02 for trend). Similar association was observed between SFA intake and JSW loss. In contrast, higher intakes of mono- (MUFA) and polyunsaturated fatty acids (PUFA), and higher ratio of PUFA to SFA were associated with a reduced JSW loss.
conclusionHigh intakes of total fat and SFA may be associated with increased structural knee OA progression, while MUFA and PUFA may reduce radiographic progression. Replication of these novel findings in other prospective studies is needed to confirm if reduction in SFA intake and increase in unsaturated fat intake lead to delayed knee OA progression.
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Registered trials
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