Evidence map›Paper›PMID 27273822›Full record

ReviewMicrobial biotechnology2017

Ecology of aspergillosis: insights into the pathogenic potency of Aspergillus fumigatus and some other Aspergillus species.

Caroline Paulussen, John E Hallsworth, Sergio Álvarez-Pérez, William C Nierman, Philip G Hamill, David Blain, Hans Rediers, Bart Lievens

Open access · goldAbstract readReview
In one paragraph

Review in Microbial biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers.

0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

167 citing papers in PubMed, 324 citations in OpenAlex.

  1. Article
  2. Virulence ofVirulence · 2026
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  9. Non-Journal of clinical microbiology · 2026
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107 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 6 countries.

Caroline PaulussenLaboratory for Process Microbial Ecology and Bioinspirational Management (PME&BIM), Department of Microbial and Molecular Systems (M2S), KU Leuven, Campus De Nayer, Sint-Katelijne-Waver, B-2860, Belgium.
John E HallsworthInstitute for Global Food Security, School of Biological Sciences, Medical Biology Centre, Queen's University Belfast, Belfast, BT9 7BL, UK.
Sergio Álvarez-PérezFaculty of Veterinary Medicine, Department of Animal Health, Universidad Complutense de Madrid, Madrid, E-28040, Spain.
William C NiermanInfectious Diseases Program, J. Craig Venter Institute, La Jolla, CA, USA.
Philip G HamillInstitute for Global Food Security, School of Biological Sciences, Medical Biology Centre, Queen's University Belfast, Belfast, BT9 7BL, UK.
David BlainInstitute for Global Food Security, School of Biological Sciences, Medical Biology Centre, Queen's University Belfast, Belfast, BT9 7BL, UK.
Hans RediersLaboratory for Process Microbial Ecology and Bioinspirational Management (PME&BIM), Department of Microbial and Molecular Systems (M2S), KU Leuven, Campus De Nayer, Sint-Katelijne-Waver, B-2860, Belgium.
Bart LievensLaboratory for Process Microbial Ecology and Bioinspirational Management (PME&BIM), Department of Microbial and Molecular Systems (M2S), KU Leuven, Campus De Nayer, Sint-Katelijne-Waver, B-2860, Belgium.
Queen's University Belfast · GBEcologie Microbienne Lyon · FRDepartment of Animal Health · VNJ. Craig Venter Institute · USKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fungi of the genus Aspergillus are widespread in the environment. Some Aspergillus species, most commonly Aspergillus fumigatus, may lead to a variety of allergic reactions and life-threatening systemic infections in humans. Invasive aspergillosis occurs primarily in patients with severe immunodeficiency, and has dramatically increased in recent years. There are several factors at play that contribute to aspergillosis, including both fungus and host-related factors such as strain virulence and host pulmonary structure/immune status, respectively. The environmental tenacity of Aspergilllus, its dominance in diverse microbial communities/habitats, and its ability to navigate the ecophysiological and biophysical challenges of host infection are attributable, in large part, to a robust stress-tolerance biology and exceptional capacity to generate cell-available energy. Aspects of its stress metabolism, ecology, interactions with diverse animal hosts, clinical presentations and treatment regimens have been well-studied over the past years. Here, we synthesize these findings in relation to the way in which some Aspergillus species have become successful opportunistic pathogens of human- and other animal hosts. We focus on the biophysical capabilities of Aspergillus pathogens, key aspects of their ecophysiology and the flexibility to undergo a sexual cycle or form cryptic species. Additionally, recent advances in diagnosis of the disease are discussed as well as implications in relation to questions that have yet to be resolved.

Indexed as

Biophysical PhenomenaHost-Pathogen InteractionsAnimalsAspergillosisAspergillusDiagnostic Tests, RoutineEcosystemHumans

Identifiers

PMID27273822
PMCPMC5328810
OpenAlexW2415728719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.