ArticleNature neuroscience2016
Decoding subjective decisions from orbitofrontal cortex.
Article in Nature neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 223 papers.
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Who cites it
223 citing papers in PubMed.
- Connectivity differences between Gulf War Illness (GWI) phenotypes during a test of attention.PloS one · 2019Trial
- Orbitofrontal value dynamics and striatal population geometry during interruption of automatic behavior.Neuron · 2026Article
- Compression as a neural mechanism of mnemonic chunking in prefrontal cortex.Current biology : CB · 2026Article
- Neural Correlates of Moral Judgment in Dilemma Versus Non-Dilemma Contexts.Brain and behavior · 2026Review
- Population geometries in frontal cortex coordinate value-based decisions.bioRxiv : the preprint server for biology · 2026Article
- Laminar architecture of a decision circuit in the mouse orbitofrontal cortex.Nature communications · 2026Article
- Intracranial recordings in humans reveal differential contributions of medial and lateral orbitofrontal cortex to approach-avoidance decision-making.Nature neuroscience · 2026Article
- Article
- Distinct High-Gamma Signals in Primate Prefrontal Cortex Differentiate Cue Information, Preference Revision, and Expected Reward During Value-Based Decisions.The European journal of neuroscience · 2026Article
- Probing biomarkers and clinical utility of reward learning across species using the Probabilistic Reward Task: 20 years of findings.Nature. Mental health · 2026Article
- Identity-specific reward expectations in orbitofrontal cortex guide goal-directed choices.PLoS biology · 2026Article
- Dynamic geometry remapping of neural activity within frontal and subcortical areas during decision-making.bioRxiv : the preprint server for biology · 2026Article
- Orbitofrontal-sensory cortical interactions in learning and adaptive decision-making.Trends in cognitive sciences · 2026Review
- Effects of overt and covert attention on decision-making dynamics in prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- Drifting population dynamics with transient resets characterize sensorimotor transformation in the monkey superior colliculus.Communications biology · 2026Article
- Learning to select computations in recurrent neural circuits.bioRxiv : the preprint server for biology · 2026Article
- Accumulation of virtual tokens towards a jackpot reward enhances performance and value encoding in dorsal anterior cingulate cortex.Nature communications · 2026Article
- A novel approach-avoidance task to study decision making under outcome uncertainty.Psychonomic bulletin & review · 2026Article
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A bio-inspired minimal model for non-stationary K-armed bandits.Biological cybernetics · 2026Article
163 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
When making a subjective choice, the brain must compute a value for each option and compare those values to make a decision. The orbitofrontal cortex (OFC) is critically involved in this process, but the neural mechanisms remain obscure, in part due to limitations in our ability to measure and control the internal deliberations that can alter the dynamics of the decision process. Here we tracked these dynamics by recovering temporally precise neural states from multidimensional data in OFC. During individual choices, OFC alternated between states associated with the value of two available options, with dynamics that predicted whether a subject would decide quickly or vacillate between the two alternatives. Ensembles of value-encoding neurons contributed to these states, with individual neurons shifting activity patterns as the network evaluated each option. Thus, the mechanism of subjective decision-making involves the dynamic activation of OFC states associated with each choice alternative.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.