ReviewThe Pediatric infectious disease journal2016
Ten-Year Study of the Stringently Defined Otitis-prone Child in Rochester, NY.
Review in The Pediatric infectious disease journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Probiotics for preventing acute upper respiratory tract infections.The Cochrane database of systematic reviews · 2022Pooled it
- Probiotics for preventing acute otitis media in children.The Cochrane database of systematic reviews · 2019Pooled it
- A bacterial pangenome association study identifies a role for polyamine metabolism and alkaline tolerance in middle ear infections.PLoS pathogens · 2026Article
- Plasma metabolomics in infancy reveals early signatures of a stringently-defined otitis-prone phenotype.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Window of Susceptibility to Acute Otitis Media Infection.Pediatrics · 2023Observational
- Adaptive immune protection of the middle ears differs from that of the respiratory tract.Frontiers in cellular and infection microbiology · 2023Article
- Viral infection in chronic otitis media with effusion in children.Frontiers in pediatrics · 2023Article
- Pneumonia, Sinusitis, Influenza and Other Respiratory Illnesses in Acute Otitis Media-Prone Children.The Pediatric infectious disease journal · 2021Article
- Novel Antimicrobial Treatment Strategy Based on Drug Delivery Systems for Acute Otitis Media.Frontiers in pharmacology · 2021Review
- Synchrony in serum antibody response to conserved proteins ofHuman vaccines & immunotherapeutics · 2020Article
- Otitis Media and Inborn Errors of Immunity.Current allergy and asthma reports · 2020Review
- Immunologic dysfunction contributes to the otitis prone condition.The Journal of infection · 2020Review
- Panel 3: Genomics, precision medicine and targeted therapies.International journal of pediatric otorhinolaryngology · 2020Review
- Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children.PloS one · 2020Article
- Serum antibody response to Moraxella catarrhalis proteins in stringently defined otitis prone children.Vaccine · 2019Article
- Impaired Proinflammatory Response in Stringently Defined Otitis-prone Children During Viral Upper Respiratory Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Etiology of acute otitis media and phenotypic-molecular characterization of Streptococcus pneumoniae isolated from children in Liuzhou, China.BMC infectious diseases · 2019Article
- Article
- Comparative Analysis of Microbiome in Nasopharynx and Middle Ear in Young Children With Acute Otitis Media.Frontiers in genetics · 2019Article
- Haemophilus influenzae-protein D specific antibody correlate with protection against acute otitis media in young children.Vaccine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
This review summarizes a prospective, longitudinal 10-year study in Rochester, NY, with virtually every clinically diagnosed acute otitis media (AOM) confirmed by bacterial culture of middle ear fluid. Children experiencing 3 episodes within 6 months or 4 episodes in 12 months were considered stringently defined otitis prone (sOP). We found stringent diagnosis compared with clinical diagnosis reduced the frequency of children meeting the OP definition from 27% to 6% resulting in 14.8% and 2.4% receiving tympanostomy tubes, respectively. Significantly more often respiratory syncytial virus infection led to AOM in sOP than non-otitis-prone children that correlated with diminished total respiratory syncytial virus-specific serum IgG. sOP children produced low levels of antibody to Streptococcus pneumoniae and Haemophilus influenzae candidate vaccine protein antigens and to routine pediatric vaccines. sOP children generated significantly fewer memory B cells, functional and memory T cells to otopathogens following nasopharyngeal colonization and AOM than non-otitis-prone children and they had defects in antigen-presenting cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.