Evidence map›Paper›PMID 27273629›Full record

ArticleNature structural & molecular biology2016

NMR as a tool to investigate the structure, dynamics and function of membrane proteins.

Binyong Liang, Lukas K Tamm

Open access · greenAbstract read
In one paragraph

Article in Nature structural & molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 108 citations in OpenAlex.

  1. Article
  2. Dynamic Decoration of DNA Scaffolds for High-Resolution Cancer Cell Subtyping.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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  10. Effect of Cholesterol on the Structure and Composition of Glyco-DIBMA Lipid Particles.Langmuir : the ACS journal of surfaces and colloids · 2023
    Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Editorial: Structural dynamics of membrane proteins, Volume II.Frontiers in molecular biosciences · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Binyong LiangCenter for Membrane and Cell Physiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Lukas K TammCenter for Membrane and Cell Physiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
University of Virginia · US

Funding

Structural Dynamics of the Exocytotic Fusion Machine in Neurons.P01GM072694 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KIESSLING, VOLKER · 2005 to 2021
$17.4M
Structure, Assembly, and Function of Outer Membrane ProteinsR01GM051329 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI TAMM, LUKAS K · 1997 to 2018
$6.4M
VIRAL SPIKE GLYCOPROTEIN-MEDIATED MEMBRANE POTENTIALR01AI030557 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI TAMM, LUKAS K · 1991 to 2022
$6.2M
NIAID NIH HHS R01 AI030557NIGMS NIH HHS P01 GM072694NIGMS NIH HHS R01 GM051329
6 · The paper itself

Abstract

Membrane-protein NMR occupies a unique niche for determining structures, assessing dynamics, examining folding, and studying the binding of lipids, ligands and drugs to membrane proteins. However, NMR analyses of membrane proteins also face special challenges that are not encountered with soluble proteins, including sample preparation, size limitation, spectral crowding and sparse data accumulation. This Perspective provides a snapshot of current achievements, future opportunities and possible limitations in this rapidly developing field.

Indexed as

Adhesins, BacterialAnimalsArchaeaBacteriaBacterial Outer Membrane ProteinsHalorhodopsinsLigandsLipid BilayersLipidsMiceMicellesModels, MolecularNuclear Magnetic Resonance, BiomolecularPrescription DrugsProtein BindingProtein ConformationAdhesins, BacterialBacterial Outer Membrane ProteinsBzrp protein, mouseHalorhodopsinsLigandsLipid BilayersLipidsMicellesOprG protein, Pseudomonas aeruginosaPrescription DrugsReceptors, GABAsensory rhodopsin II protein, archaealSensory RhodopsinsYadA protein, Yersinia

Identifiers

PMID27273629
PMCPMC5444674
OpenAlexW2418297362

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.