ArticleScientific reports2016
Common UCP2 variants contribute to serum urate concentrations and the risk of hyperuricemia.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Sex differences in the relationship between body mass index in Chinese adolescents and future risk of hypertension: a decade-long cohort study.BMC pediatrics · 2025Article
- Whole-Exome Sequencing Identifies a NovelFrontiers in cell and developmental biology · 2022Article
- Association of 45-bp ins/del polymorphism of uncoupling protein 2 (UCP2) and susceptibility to nonalcoholic fatty liver and type 2 diabetes mellitus in North-west of Iran.BMC research notes · 2021Article
- Epistatic interaction between PKD2 and ABCG2 influences the pathogenesis of hyperuricemia and gout.Hereditas · 2020Article
- Blood cell transcript levels in 5-year-old children as potential markers of breastfeeding effects in those small for gestational age at birth.Journal of translational medicine · 2019Article
- Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss.The journal of international advanced otology · 2018Article
- Genetic variants in two pathways influence serum urate levels and gout risk: a systematic pathway analysis.Scientific reports · 2018Article
- Elevated serum urate is a potential factor in reduction of total bilirubin: a Mendelian randomization study.Oncotarget · 2017Article
- Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout.Protein & cell · 2017Article
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Authors and funding
16 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevated serum urate, which is regulated at multiple levels including genetic variants, is a risk factor for gout and other metabolic diseases. This study aimed to investigate the association between UCP2 variants and serum urate as well as hyperuricemia in a Chinese population. In total, 4332 individuals were genotyped for two common UCP2 variants, -866G/A and Ala55Val. These loci were not associated either serum urate level or with a risk of hyperuricemia in the total group of subjects. However, in females, -866G/A and Ala55Val were associated with a lower serum urate (P = 0.006 and 0.014, seperately) and played a protective role against hyperuricemia (OR = 0.80, P = 0.018; OR = 0.79, P = 0.016). These associations were not observed in the males. After further stratification, the two loci were associated with serum urate in overweight, but not underweight females. The haplotype A-T (-866G/A-Ala55Val) was a protective factor for hyperuricemia in the female subgroup (OR = 0.80, P = 0.017). This present study identified a novel gene, UCP2, that influences the serum urate concentration and the risk of hyperuricemia, and the degree of association varies with gender and BMI levels.
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