ArticleScientific reports2016
Arabidopsis LBP/BPI related-1 and -2 bind to LPS directly and regulate PR1 expression.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 30 citations in OpenAlex.
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- Effects of LPS fromMicroorganisms · 2023Article
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- Unraveling the sugar code: the role of microbial extracellular glycans in plant-microbe interactions.Journal of experimental botany · 2021Review
- Lipopolysaccharide Enhances Tanshinone Biosynthesis via a CaInternational journal of molecular sciences · 2020Article
- Identification of MAMP-Responsive Plasma Membrane-Associated Proteins inPathogens (Basel, Switzerland) · 2020Article
- Prospects of Gene Knockouts in the Functional Study of MAMP-Triggered Immunity: A Review.International journal of molecular sciences · 2020Review
- Bactericidal/Permeability-Increasing Protein Improves Cognitive Impairment in Diabetic MiceFrontiers in physiology · 2020Article
- The Role ofPathogens (Basel, Switzerland) · 2019Review
- Apoplastic invasion patterns triggering plant immunity: plasma membrane sensing at the frontline.Molecular plant pathology · 2019Review
- Osteoarthritis induced by destabilization of the medial meniscus is reduced in germ-free mice.Osteoarthritis and cartilage · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipopolysaccharide (LPS) is a major constituent of the outer membrane of Gram-negative bacteria and acts as a pathogen-associated molecular pattern that triggers immune responses in both plants and animals. LPS-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI), which bind to LPS and play important roles in immunity of mammals, have been well studied. However, the molecule contributing to LPS binding in plants is mostly unknown. The Arabidopsis genome carries two genes encoding LBP/BPI-related proteins which we designated as AtLBP/BPI related-1 (AtLBR-1) and AtLBP/BPI related-2 (AtLBR-2). We found that their N-terminal domains were co-purified with cell wall-derived LPS when expressed in E. coli. Since this finding implied the direct binding of AtLBRs to LPS, we also confirmed binding by using LPS-free AtLBRs and purified LPS. AtLBRs directly bind to both rough and smooth types of LPS. We also demonstrated that LPS-treated atlbr mutant Arabidopsis exhibit a significant delay of induction of defence-related gene pathogenesis-related 1 (PR1) but no other PR genes. Furthermore, LPS-treated atlbr mutants showed defects in reactive oxygen species (ROS) generation. These results demonstrate that, as well as LBP and BPI of mammals, AtLBRs also play an important role in the LPS-induced immune response of plants.
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