ArticleScientific reports2016
Yap/Taz transcriptional activity in endothelial cells promotes intramembranous ossification via the BMP pathway.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Loss of Endothelial YAP/TAZ Reduces the Size of Chronic Stroke Lesions and Alters the Endothelial Environment.Journal of the American Heart Association · 2026Article
- Restoring immune homeostasis in the spinal microenvironment: targeting mechano-inflammation and immunometabolic reprogramming.Frontiers in immunology · 2026Review
- YAP regulates transcriptional programs for layer-specific periosteal expansion during fracture repair.Science advances · 2025Article
- Role of YAP in hematopoietic differentiation and erythroid lineage specification of human-induced pluripotent stem cells.Stem cell research & therapy · 2023Article
- Review
- Endothelial-derived angiocrine factors as instructors of embryonic development.Frontiers in cell and developmental biology · 2023Review
- Role of Yes-associated protein (YAP) in regulation of mesenchymal stem cell tenogenic differentiation.Journal of molecular histology · 2022Article
- Local fluid shear stress operates a molecular switch to drive fetal semilunar valve extension.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Article
- E-cigarette Aerosol Mixtures Inhibit Biomaterial-Induced Osseointegrative Cell Phenotypes.Materialia · 2021Article
- Role of Glycosylation in Vascular Calcification.International journal of molecular sciences · 2021Review
- Molecular mechanisms of intermuscular bone development in fish: a review.Zoological research · 2021Review
- 3D-Bioprinting Strategies Based on In Situ Bone-Healing Mechanism for Vascularized Bone Tissue Engineering.Micromachines · 2021Review
- Yes-associated protein promotes tumour necrosis factor α-treated cementoblast mineralization partly by inactivating NF-κB pathway.Journal of cellular and molecular medicine · 2020Article
- Article
- Role of Hippo-YAP1/TAZ pathway and its crosstalk in cardiac biology.International journal of biological sciences · 2020Review
- Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging.The Journal of clinical investigation · 2018Article
- Nanofibers Regulate Single Bone Marrow Stem Cell Osteogenesis via FAK/RhoA/YAP1 Pathway.ACS applied materials & interfaces · 2018Article
- Ablation of protein phosphatase 5 (PP5) leads to enhanced both bone and cartilage development in mice.Cell death & disease · 2018Article
- Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development.Developmental cell · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteogenesis is categorized into two groups based on developmental histology, intramembranous and endochondral ossification. The role of blood vessels during endochondral ossification is well known, while their role in intramembranous ossification, especially the intertissue pathway, is poorly understood. Here, we demonstrate endothelial Yap/Taz is a novel regulator of intramembranous ossification in zebrafish. Appropriate blood flow is required for Yap/Taz transcriptional activation in endothelial cells and intramembranous ossification. Additionally, Yap/Taz transcriptional activity in endothelial cells specifically promotes intramembranous ossification. BMP expression by Yap/Taz transactivation in endothelial cells is also identified as a bridging factor between blood vessels and intramembranous ossification. Furthermore, the expression of Runx2 in pre-osteoblast cells is a downstream target of Yap/Taz transcriptional activity in endothelial cells. Our results provide novel insight into the relationship between blood flow and ossification by demonstrating intertissue regulation.
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