ArticleNature communications2016
The Arabidopsis acetylated histone-binding protein BRAT1 forms a complex with BRP1 and prevents transcriptional silencing.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 44 citations in OpenAlex.
- A mutation in CsBRP1, encoding a PHD-type domain-containing protein, causes semi-dwarfism in cucumber (Cucumis sativus L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- The GTE4-EML chromatin reader complex concurrently recognizes histone acetylation and H3K4 trimethylation in Arabidopsis.The Plant cell · 2024Article
- Spotlight on Plant Bromodomain Proteins.Biology · 2023Review
- Article
- Creativity comes from interactions: modules of protein interactions in plants.The FEBS journal · 2022Review
- Novel variant in BRAT1 with the lethal neonatal rigidity and multifocal seizure syndrome.Pediatric research · 2022Article
- Novel Biallelic Variant in theFrontiers in genetics · 2022Article
- DREAM complex suppresses DNA methylation maintenance genes and precludes DNA hypermethylation.Nature plants · 2020Article
- A plant-specific SWR1 chromatin-remodeling complex couples histone H2A.Z deposition with nucleosome sliding.The EMBO journal · 2020Article
- Redox Components: Key Regulators of Epigenetic Modifications in Plants.International journal of molecular sciences · 2020Review
- Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin.Nature communications · 2018Article
- The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing.The EMBO journal · 2018Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transposable elements and other repetitive DNA sequences are usually subject to DNA methylation and transcriptional silencing. However, anti-silencing mechanisms that promote transcription in these regions are not well understood. Here, we describe an anti-silencing factor, Bromodomain and ATPase domain-containing protein 1 (BRAT1), which we identified by a genetic screen in Arabidopsis thaliana. BRAT1 interacts with an ATPase domain-containing protein, BRP1 (BRAT1 Partner 1), and both prevent transcriptional silencing at methylated genomic regions. Although BRAT1 mediates DNA demethylation at a small set of loci targeted by the 5-methylcytosine DNA glycosylase ROS1, the involvement of BRAT1 in anti-silencing is largely independent of DNA demethylation. We also demonstrate that the bromodomain of BRAT1 binds to acetylated histone, which may facilitate the prevention of transcriptional silencing. Thus, BRAT1 represents a potential link between histone acetylation and transcriptional anti-silencing at methylated genomic regions, which may be conserved in eukaryotes.
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