Evidence map›Paper›PMID 27273168›Full record

ReviewNature reviews. Gastroenterology & hepatology2016

The role of the gut microbiota in NAFLD.

Christopher Leung, Leni Rivera, John B Furness, Peter W Angus

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 544 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
544citing papers in PubMed, 10 pooled it
48.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04671186 nacompletednot on this mapstarted 2020, after this paper: background citation

Role of Probiotics in Treatment of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) Patients by Assessing With Fibroscan

TypeinterventionalSponsorNorthwell HealthRan2020 to 2023Enrolled47ConditionsNon-Alcoholic Fatty Liver DiseaseArmsCulturelle (Lactobacillus rhamnosus strain GG), Placebo
NCT06682663 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

Evaluation of the Effect of Live Streaming Exercise on the Improvement of Hepatic Steatosis and Fibrosis in Pregnant Women with MASLD and Its Study Based on the Liver-gut Axis Mechanism.

TypeinterventionalSponsorPeking UniversityRan2024 to 2026Enrolled220ConditionsMetabolic Dysfunction-associated Steatotic Liver DiseaseArmsLive Streaming Exercise
3 · Its place in the literature

Who cites it

544 citing papers in PubMed, 10 syntheses or guidelines pooled it, 974 citations in OpenAlex.

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  5. Efficacy of interventions with live combinedFrontiers in pharmacology · 2025
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  20. The Role of Gut Microbiota in Liver Regeneration After Partial Hepatectomy: New Evidence From Animal and Human Studies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review

484 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Christopher LeungDepartment of Medicine, The University of Melbourne, Austin Health, Heidelberg, Melbourne, VIC 3084, Australia.
Leni RiveraMetabolic Research Unit, School of Medicine, Deakin University, Geelong, VIC 3216, Australia.
John B FurnessDepartment of Anatomy and Neuroscience, University of Melbourne, Grattan Street, Parkville, VIC 3010, Australia.
Peter W AngusDepartment of Medicine, The University of Melbourne, Austin Health, Heidelberg, Melbourne, VIC 3084, Australia.
University of Melbourne · AUAustin Hospital · AUDeakin University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NAFLD is now the most common cause of liver disease in Western countries. This Review explores the links between NAFLD, the metabolic syndrome, dysbiosis, poor diet and gut health. Animal studies in which the gut microbiota are manipulated, and observational studies in patients with NAFLD, have provided considerable evidence that dysbiosis contributes to the pathogenesis of NAFLD. Dysbiosis increases gut permeability to bacterial products and increases hepatic exposure to injurious substances that increase hepatic inflammation and fibrosis. Dysbiosis, combined with poor diet, also changes luminal metabolism of food substrates, such as increased production of certain short-chain fatty acids and alcohol, and depletion of choline. Changes to the microbiome can also cause dysmotility, gut inflammation and other immunological changes in the gut that might contribute to liver injury. Evidence also suggests that certain food components and lifestyle factors, which are known to influence the severity of NAFLD, do so at least in part by changing the gut microbiota. Improved methods of analysis of the gut microbiome, and greater understanding of interactions between dysbiosis, diet, environmental factors and their effects on the gut-liver axis should improve the treatment of this common liver disease and its associated disorders.

Indexed as

Bile Acids and SaltsDietDisease ProgressionEthanolExerciseFatty Acids, VolatileFungiGastrointestinal MicrobiomeGastrointestinal MotilityGlucoseGram-Negative BacteriaGram-Positive BacteriaHost-Pathogen InteractionsHumansIntestinesLiverBile Acids and SaltsEthanolFatty Acids, VolatileGlucoseMethylaminesPhosphatidylcholinesPrebioticsReceptors, G-Protein-Coupled

Identifiers

PMID27273168
OpenAlexW2415314033

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.