ArticleScientific reports2016
Sesterterpene ophiobolin biosynthesis involving multiple gene clusters in Aspergillus ustus.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- From Phytotoxin to Cell-Death Probe: Ophiobolin A and Related Sesterterpenoids in Membrane Stress and Non-Apoptotic Cell Death.Molecules (Basel, Switzerland) · 2026Review
- Pyruvate decarboxylase and its lysine succinylation contribute to the development and metabolite biosynthesis in pathogenic fungusMycology · 2026Article
- Comparative Genomics Reveals Conserved Ophiobolin Biosynthetic Gene Cluster and Necrotrophic Adaptation in Bipolaris oryzae.The plant pathology journal · 2025Article
- De novo production of bioactive sesterterpenoid ophiobolins in Saccharomyces cerevisiae cell factories.Microbial cell factories · 2024Article
- Genome mining and biosynthetic pathways of marine-derived fungal bioactive natural products.Frontiers in microbiology · 2024Review
- Research Progress on Fungal Sesterterpenoids Biosynthesis.Journal of fungi (Basel, Switzerland) · 2022Review
- The Biosynthesis and Transport of Ophiobolins inInternational journal of molecular sciences · 2022Article
- A marine-derived small molecule induces immunogenic cell death against triple-negative breast cancer through ER stress-CHOP pathway.International journal of biological sciences · 2022Article
- Molecular Basis for Sesterterpene Diversity Produced by Plant Terpene Synthases.Plant communications · 2020Article
- A Review of Terpenes from Marine-Derived Fungi: 2015-2019.Marine drugs · 2020Review
- Antibacterial scalarane fromBeilstein journal of organic chemistry · 2020Article
- Toxicity, Pharmacokinetics, and Gut Microbiome of Oral Administration of Sesterterpene MHO7 Derived from a Marine Fungus.Marine drugs · 2019Article
- New Ophiobolin Derivatives from the Marine FungusMarine drugs · 2019Article
- Structural and Chemical Biology of Terpenoid Cyclases.Chemical reviews · 2017Review
- The Biological Activities of Sesterterpenoid-Type Ophiobolins.Marine drugs · 2017Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Terpenoids are the most diverse and abundant natural products among which sesterterpenes account for less than 2%, with very few reports on their biosynthesis. Ophiobolins are tricyclic 5-8-5 ring sesterterpenes with potential pharmaceutical application. Aspergillus ustus 094102 from mangrove rizhosphere produces ophiobolin and other terpenes. We obtained five gene cluster knockout mutants, with altered ophiobolin yield using genome sequencing and in silico analysis, combined with in vivo genetic manipulation. Involvement of the five gene clusters in ophiobolin synthesis was confirmed by investigation of the five key terpene synthesis relevant enzymes in each gene cluster, either by gene deletion and complementation or in vitro verification of protein function. The results demonstrate that ophiobolin skeleton biosynthesis involves five gene clusters, which are responsible for C15, C20, C25, and C30 terpenoid biosynthesis.
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