ArticleAge (Dordrecht, Netherlands)2016
Association between gait characteristics and endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease.
Article in Age (Dordrecht, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Effects of NADThe Journal of pharmacology and experimental therapeutics · 2025Trial
- Noninvasive low-level tragus stimulation attenuates inflammation and oxidative stress in acute heart failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Trial
- Effects of Long-Term Home Exercise in Participants With Peripheral Artery Disease.Journal of the American Heart Association · 2023Trial
- Changes in vascular and inflammatory biomarkers after exercise rehabilitation in patients with symptomatic peripheral artery disease.Journal of vascular surgery · 2019Trial
- Serum and Skin Carotenoid Levels in Older Adults with and Without Metabolic Syndrome: A Cross-Sectional Study.Nutrients · 2025Article
- Prevalence of Meeting Daily Step Count Recommendations in Cardiovascular Patients With and Without Metabolic Syndrome.American journal of medicine open · 2025Article
- Fibrinogen-to-Albumin Ratio as a Novel Predictor of Intracerebral Hemorrhage in Maintenance Hemodialysis Patients.Journal of inflammation research · 2025Article
- Association between subjective walking speed and metabolic diseases in individuals with obesity: a cross-sectional analysis.Scientific reports · 2024Article
- Clinical utility of simple subjective gait speed for the risk stratification of heart failure in a primary prevention setting.Scientific reports · 2022Observational
- Microvascular dysfunction and neurovascular uncoupling are exacerbated in peripheral artery disease, increasing the risk of cognitive decline in older adults.American journal of physiology. Heart and circulatory physiology · 2022Article
- Relationship between tooth loss and sarcopenia in suburban community-dwelling older adults in Shanghai and Tianjin of China.Scientific reports · 2022Article
- Light and moderate intensity physical activity are associated with better ambulation, quality of life, and vascular measurements in patients with claudication.Journal of vascular surgery · 2022Article
- Abnormal vibration perception threshold alters the gait features in type 2 diabetes mellitus patients.Frontiers in endocrinology · 2022Article
- Supervised Exercise Training Improves 6 min Walking Distance and Modifies Gait Pattern during Pain-Free Walking Condition in Patients with Symptomatic Lower Extremity Peripheral Artery Disease.Sensors (Basel, Switzerland) · 2021Article
- Physical Activity in Polluted Air-Net Benefit or Harm to Cardiovascular Health? A Comprehensive Review.Antioxidants (Basel, Switzerland) · 2021Review
- Article
- Association between meeting daily step count goals with ambulatory function and quality of life in patients with claudication.Journal of vascular surgery · 2021Article
- Evaluation of Biosafety, Antiobesity, and Endothelial Cells Proliferation Potential of Basil Seed Extract Loaded Organic Solid Lipid Nanoparticle.Frontiers in pharmacology · 2021Article
- Comparison of hemorrhagic and ischemic stroke after allogeneic hematopoietic stem cell transplantation.Bone marrow transplantation · 2020Article
- Diet is associated with ankle-brachial index, inflammation, and ambulation in patients with intermittent claudication.Journal of vascular surgery · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The aim of the study was to determine whether gait characteristics were associated with endothelial cell inflammation, oxidative stress, and apoptosis and with circulating biomarkers of inflammation and antioxidant capacity in older patients with symptomatic peripheral artery disease (PAD). Gait measurements of 231 symptomatic men and women with PAD were assessed during a 4-m walk test. Patients were further characterized on endothelial effects of circulating factors present in the sera using a cell culture-based bioassay on primary human arterial endothelial cells and on circulating inflammatory and vascular biomarkers. In a multivariate regression model for gait speed, the significant independent variables were age (p < 0.001), intercellular cell adhesion molecule-1 (ICAM-1) (p < 0.001), diabetes (p = 0.003), sex (p = 0.003), and history of cerebrovascular accidents (p = 0.021). In multivariate analyses for gait cadence, the significant independent predictors included high-sensitivity C-reactive protein (HsCRP) (p < 0.001), diabetes (p = 0.001), and hypertension (p = 0.001). In a multivariate regression model for gait stride length, the significant independent variables were HsCRP (p < 0.001), age (p < 0.001), ICAM-1 (p < 0.001), hypertension (p = 0.002), cellular reactive oxygen species production (p = 0.007), and sex (p = 0.008). Higher levels of circulating biomarkers of inflammation and endothelial cell oxidative stress were associated with slower gait speed, slower cadence, and shorter stride length in older symptomatic patients with PAD. Additionally, this profile of impaired gait was more evident in older patients, in women, and in those with diabetes, hypertension, and history of cerebrovascular accidents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.