Evidence map›Paper›PMID 27273076›Full record

ArticleJournal of neurovirology2016

Progressive multifocal leukoencephalopathy in a patient without apparent immunosuppression.

Jessie Grewal, Poorvi Dalal, Michelle Bowman, Behiye Kaya, José Javier Otero, Jaime Imitola

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Journal of neurovirology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jessie GrewalDepartment of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Poorvi DalalDepartment of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Michelle BowmanDepartment of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Behiye KayaDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
José Javier OteroDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Jaime ImitolaDepartment of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA. jaime.imitola@osumc.edu.
The Ohio State University Wexner Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progressive multifocal leukoencephalopathy (PML) is a viral demyelinating disease due to the reactivation of the JC virus (JCV), which usually occurs in the context of immunosuppression in HIV infection, malignancy, or in patients on disease modifying therapy for autoimmune diseases, such as multiple sclerosis (MS) and Crohn's disease. Notably, there is growing recognition that PML can occur in patients with transient immune dysfunction. Here, we present a case of a 55-year-old man without history of immunosuppression or evidence of ICL who was diagnosed with PML on brain biopsy. We will discuss the potential etiologies of mild and transient immunosuppression that can lead to PML with non-apparent immunosuppression.

Indexed as

BrainCognitive DysfunctionDiplopiaDisease ProgressionFatal OutcomeHumansImmunocompetenceJC VirusLeukoencephalopathy, Progressive MultifocalMaleMiddle AgedUrinary IncontinenceVertigoImmunocompetent hostProgressive multifocal leukoencephalopathy

Identifiers

PMID27273076
OpenAlexW2415962744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.