ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Working Memory Impairing Actions of Corticotropin-Releasing Factor (CRF) Neurotransmission in the Prefrontal Cortex.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Regulatory Role of PFC Corticotropin-Releasing Factor System in Stress-Associated Depression Disorders: A Systematic Review.Cellular and molecular neurobiology · 2023Pooled it
- Neurochemical and Circuit Heterogeneity of Cognition-Modulating Prefrontal Corticotropin-Releasing Factor Neurons.Biological psychiatry · 2026Article
- A unifying theory of brain signaling and its possible role in acquired chronic disease.Frontiers in neuroscience · 2026Article
- Prefrontal parvalbumin interneurons mediate CRHR1-dependent early-life stress-induced cognitive deficits in adolescent male mice.Molecular psychiatry · 2025Article
- Subregion-specific transcriptomic profiling of rat brain reveals sex-distinct gene expression impacted by adolescent stress.Neuroscience · 2024Article
- Heightened SAM- and HPA-axis activity during acute stress impairs decision-making: A systematic review on underlying neuropharmacological mechanisms.Neurobiology of stress · 2024Article
- Associations of lamplight exposure during sleep and sleep duration with attention-deficit/hyperactivity disorder among preschool children in China.Frontiers in psychiatry · 2024Article
- Article
- Estrus cycle-dependent working memory effects of prefrontal cortex corticotropin-releasing factor neurotransmission.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Ethanol withdrawal-induced adaptations in prefrontal corticotropin releasing factor receptor 1-expressing neurons regulate anxiety and conditioned rewarding effects of ethanol.Molecular psychiatry · 2022Article
- Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders.Frontiers in neural circuits · 2022Review
- Prefrontal corticotropin-releasing factor neurons impair sustained attention via distal transmitter release.The European journal of neuroscience · 2021Article
- Convergent neuroendocrine mechanisms of social buffering and stress contagion.Hormones and behavior · 2021Review
- Stress Regulation of Sustained Attention and the Cholinergic Attention System.Biological psychiatry · 2020Article
- Role of corticotropin-releasing factor in alcohol and nicotine addiction.Brain research · 2020Review
- Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Inhibitory Control of Basolateral Amygdalar Transmission to the Prefrontal Cortex by Local Corticotrophin Type 2 Receptor.The international journal of neuropsychopharmacology · 2020Article
- Turning the 'Tides on Neuropsychiatric Diseases: The Role of Peptides in the Prefrontal Cortex.Frontiers in behavioral neuroscience · 2020Article
- Bidirectional Associations Between Stress and Reward Processing in Children and Adolescents: A Longitudinal Neuroimaging Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Corticotropin-Releasing Factor (CRF) circuit modulation of cognition and motivation.Neuroscience and biobehavioral reviews · 2019Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The prefrontal cortex (PFC) regulates cognitive processes critical for goal-directed behavior. PFC cognitive dysfunction is implicated in multiple psychopathologies, including attention deficit hyperactivity disorder (ADHD). Although it has long been known that corticotropin-releasing factor (CRF) and CRF receptors are prominent in the PFC, the cognitive effects of CRF action within the PFC are poorly understood. The current studies examined whether CRF receptor activation in the PFC modulates cognitive function in rats as measured in a delayed response task of spatial working memory. CRF dose-dependently impaired working memory performance when administered either intracerebroventricularly (ICV) or directly into the PFC. The working memory actions of CRF in the PFC were topographically organized, with impairment observed only following CRF infusions into the caudal dorsomedial PFC (dmPFC). Additional studies examined whether endogenous CRF modulates working memory. Both ICV and intra-dmPFC administration of the nonselective CRF antagonist, D-Phe-CRF, dose-dependently improved working memory performance. To better assess the translational potential of CRF antagonists, we examined the cognitive effects of systemic administration of the CRF1 receptor selective antagonist, NBI 35965. Similar procognitive actions were observed in these studies. These results are the first to demonstrate that CRF acts in the PFC to regulate PFC-dependent cognition. Importantly, the ability of CRF antagonists to improve working memory is identical to that seen with all approved treatments for ADHD. These observations suggest that CRF antagonists may represent a novel approach for the treatment of ADHD and other disorders associated with dysregulated prefrontal cognitive function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.