ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Estrogen's Effects on Excitatory Synaptic Transmission Entail Integrin and TrkB Transactivation and Depend Upon β1-integrin function.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Hippocampal tissue mechanics are sensitive to fluctuations in oestrogen across the rat oestrous cycle.Brain communications · 2026Article
- The Role and Mechanism of Estrogen in Perimenopausal Depression.Current neuropharmacology · 2026Review
- The how and why for multiple forms of hippocampal LTP.Frontiers in synaptic neuroscience · 2026Review
- Depletion of mmu-miR-185 enhances osteocyte connectivity and suppresses bone fragility through the interaction between ARL8B and RAB5A.Stem cell research & therapy · 2025Article
- Contributions of site- and sex-specific LTPs to everyday memory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Sex-Specific Mechanisms Underlie Long-Term Potentiation at Hippocampus→Medium Spiny Neuron Synapses in the Medial Shell of the Nucleus Accumbens.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Sex differences in synaptic plasticity underlying learning.Journal of neuroscience research · 2023Review
- Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder inLife science alliance · 2023Article
- NX210c Peptide Promotes Glutamatergic Receptor-Mediated Synaptic Transmission and Signaling in the Mouse Central Nervous System.International journal of molecular sciences · 2022Article
- Extracellular matrix metalloproteinase-9 (MMP-9) is required in female mice for 17β-estradiol enhancement of hippocampal memory consolidation.Psychoneuroendocrinology · 2022Article
- Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents.Neurobiology of disease · 2022Article
- TrbK controls astrocyte-driven oligodendrocyte copper poisoning.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Dysregulated copper transport in multiple sclerosis may cause demyelination via astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Estradiol Regulation of the Prelimbic Cortex and the Reinstatement of Cocaine Seeking in Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- 17β-estradiol activation of dorsal hippocampal TrkB is independent of increased mature BDNF expression and is required for enhanced memory consolidation in female mice.Psychoneuroendocrinology · 2021Article
- Review
- Activation of oestrogen receptor α induces a novel form of LTP at hippocampal temporoammonic-CA1 synapses.British journal of pharmacology · 2020Article
- 17α Estradiol promotes plasticity of spared inputs in the adult amblyopic visual cortex.Scientific reports · 2019Article
- β1-Integrins in the Developing Orbitofrontal Cortex Are Necessary for Expectancy Updating in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Soluble Factors from Human Olfactory Neural Stem/Progenitor Cells Influence the Fate Decisions of Hippocampal Neural Precursor Cells.Molecular neurobiology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Estradiol (E2) perfusion rapidly increases the strength of fast excitatory transmission and facilitates long-term potentiation in the hippocampus, two effects likely related to its memory-enhancing properties. Past studies showed that E2's facilitation of transmission involves activation of RhoA signaling leading to actin polymerization in dendritic spines. Here we report that brief exposure of adult male hippocampal slices to 1 nM E2 increases the percentage of postsynaptic densities associated with high levels of immunoreactivity for activated forms of the BDNF receptor TrkB and β1-integrins, two synaptic receptors that engage actin regulatory RhoA signaling. The effects of E2 on baseline synaptic responses were unaffected by pretreatment with the TrkB-Fc scavenger for extracellular BDNF or TrkB antagonism, but were eliminated by neutralizing antisera for β1-integrins. E2 effects on synaptic responses were also absent in conditional β1-integrin knockouts, and with inhibition of matrix metalloproteinases, extracellular enzymes that generate integrin ligands. We propose that E2, acting through estrogen receptor-β, transactivates synaptic TrkB and β1-integrin, and via mechanisms dependent on integrin activation and signaling, reversibly reorganizes the spine cytoskeleton and thereby enhances synaptic responses in adult hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.