ArticleEnvironmental science and pollution research international2016
Long-term effects of antibiotics, norfloxacin, and sulfamethoxazole, in a partial life-cycle study with zebrafish (Danio rerio): effects on growth, development, and reproduction.
Article in Environmental science and pollution research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Environmental assessment of antibiotic toxicity under climate change-related temperature and pH scenarios using Danio rerio.Fish physiology and biochemistry · 2026Article
- Article
- Spatiotemporal patterns of antimicrobial resistance in shared human-animal waterpoints in the Maasai Mara Ecosystem, Kenya.PLOS global public health · 2026Article
- A Pretty Kettle of Fish: A Review on the Current Challenges in Mediterranean Teleost Reproduction.Animals : an open access journal from MDPI · 2024Review
- Biological toxicity of sulfamethoxazole in aquatic ecosystem on adult zebrafish (Danio rerio).Scientific reports · 2024Article
- Transcriptomic Association Analysis of the Metabolic Mechanism of Sulfamethoxazole in Channel Catfish (Animals : an open access journal from MDPI · 2024Article
- Dietary β-Glucan Alleviates Antibiotic-Associated Side Effects by Increasing the Levels of Antioxidant Enzyme Activities and Modifying Intestinal Microbiota in Pacific White Shrimp (Antioxidants (Basel, Switzerland) · 2023Article
- Occurrence, Bioaccumulation, Metabolism and Ecotoxicity of Fluoroquinolones in the Aquatic Environment: A Review.Toxics · 2023Review
- Chronic Exposure to Environmentally Relevant Concentrations of Tetracycline Perturbs Gut Homeostasis in Zebrafish.Environment & health (Washington, D.C.) · 2023Article
- Article
- Determination of the pharmaceuticals-nano/microplastics in aquatic systems by analytical and instrumental methods.Environmental monitoring and assessment · 2022Review
- Emergence of phenotypic and genotypic resistance in the intestinal microbiota of rainbow trout (Oncorhynchus mykiss) exposed long-term to sub-inhibitory concentrations of sulfamethoxazole.Ecotoxicology (London, England) · 2021Article
- The use of non-target high-resolution mass spectrometry screening to detect the presence of antibiotic residues in urban streams of Greensboro North Carolina.Journal of environmental health science & engineering · 2021Article
- Antibiotic accumulation, growth performance, intestinal diversification, and function of Nile tilapia (Oreochromis niloticus) feed by diets supplemented with different doses of sulfamethoxazole.Environmental science and pollution research international · 2021Article
- Can pharmaceutical drugs used to treat Covid-19 infection leads to human health risk? A hypothetical study to identify potential risk.The Science of the total environment · 2021Article
- Zebrafish as a Screening Model to Study the Single and Joint Effects of Antibiotics.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Pharmaceutical effluent: a critical link in the interconnected ecosystem promoting antimicrobial resistance.Environmental science and pollution research international · 2021Review
- Distribution, Removal, and Risk Assessment of Pharmaceuticals and Their Metabolites in Five Sewage Plants.International journal of environmental research and public health · 2019Article
- Antibiotic Pollution in the Environment: From Microbial Ecology to Public Policy.Microorganisms · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A partial life-cycle study with zebrafish (Danio rerio) was conducted to evaluate the long-term effects of antibiotics, norfloxacin (NOR) and sulfamethoxazole (SMX). A series of bio-endpoints correlated to the growth, development, and reproduction was assessed. The results showed that the body weight and the condition factor were depressed by SMX at 200 μg/L during the growth period. Meanwhile, the activities of metabolic enzyme (ethoxyresorufin O-deethylase, EROD) and antioxidant enzymes (superoxide dismutase, SOD and catalase, CAT) were stimulated in all cases. The consequences of parental exposure to antibiotics for the next generation were also examined. The egg production of parents were depressed by the 200 μg/L NOR and SMX alone or in combination. Similarly, decreased hatching, survival, and enhanced development abnormality of the next generation also occurred after parental exposure to SMX at the highest concentration. The heartbeat however was not altered in all cases. Furthermore, there was no significant difference in the bio-endpoints between the combined and individual treatment in most cases, with the exception of lower EROD activity and egg production in the co-treatment. The results suggest that long-term exposure to NOR and SMX at environmentally relevant concentrations, individually and in a mixture, may not significantly pose a threat to the growth, development, and reproduction of zebrafish, and an adverse effect may be expected at high concentration.
Indexed as
Identifiers
27272703What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.