ArticleJAMA2016
Treatment of Fatigue in Parkinson Disease.
Article in JAMA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04267107 (Managing Fatigue), which is not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Managing Fatigue: The Individual Program in People Living With Parkinson's Disease- A Protocol for a Feasibility Study
Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Acupuncture for Parkinson's Disease: A Narrative Review of Clinical Efficacy and Mechanistic Insights.Neuropsychiatric disease and treatment · 2025Review
- Modafinil, an atypical CNS stimulant?Advances in pharmacology (San Diego, Calif.) · 2024Article
- Depressive Symptoms and Their Impact on Quality of Life in Parkinson's Disease: An Exploratory Network Analysis Approach.Journal of clinical medicine · 2023Article
- Characteristics of fatigue in Parkinson's disease: A longitudinal cohort study.Frontiers in aging neuroscience · 2023Article
- Looking deeper: does a connection exist between fatigue and attentional deficits in Parkinson's disease? A conceptual framework.Frontiers in neurology · 2023Article
- Managing Fatigue in Parkinson's Disease: Protocol for a Pilot Randomized Controlled Trial.Canadian journal of occupational therapy. Revue canadienne d'ergotherapie · 2022Article
- Effect of acupuncture for non-motor symptoms in patients with Parkinson's disease: A systematic review and meta-analysis.Frontiers in aging neuroscience · 2022Article
- Data-Driven Prediction of Fatigue in Parkinson's Disease Patients.Frontiers in artificial intelligence · 2021Article
- Association between fatigue and motor progression in Parkinson's disease in southern Chinese.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Fatigue in Parkinson's Disease Associates with Lower Ambulatory Diastolic Blood Pressure.Journal of Parkinson's disease · 2019Article
- The dimensionality of fatigue in Parkinson's disease.Journal of translational medicine · 2018Article
- Fatigue as a symptom or comorbidity of neurological diseases.Nature reviews. Neurology · 2017Review
- The ICM research agenda on intensive care unit-acquired weakness.Intensive care medicine · 2017Review
- Validation of the Parkinson Fatigue Scale in Chinese Parkinson's disease patients.Brain and behavior · 2017Article
- Prolonged Walking with a Wearable System Providing Intelligent Auditory Input in People with Parkinson's Disease.Frontiers in neurology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
clinical questionWhich pharmacological and nonpharmacological interventions are associated with improvement in general, physical, or mental fatigue and minimal adverse effects in patients with Parkinson disease (PD)? BOTTOM LINE: Rasagiline, modafinil, and doxepin are associated with improvement in fatigue and are not associated with increased risk of adverse effects in patients with PD. However, the quality of evidence is limited and does not provide a clear basis for treatment decisions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.