Evidence map›Paper›PMID 27272517›Full record

Trial reportLasers in medical science2016

Low-level laser therapy for treatment of chemotherapy-induced oral mucositis in childhood: a randomized double-blind controlled study.

Francesca Amadori, Elena Bardellini, Giulio Conti, Nicola Pedrini, Richard Fabian Schumacher, Alessandra Majorana

Open access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Lasers in medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 10 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 10 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Pooled it
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  3. Efficacy of photobiomodulation in the treatment of oral mucositis in patients undergoing antineoplastic therapy: systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
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  7. Systematic review of photobiomodulation for the management of oral mucositis in cancer patients and clinical practice guidelines.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
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  11. Trial
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  13. Article
  14. Review
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  16. Nursing care approaches to oral mucositis in pediatric oncology clinics: a cross-sectional study from Türkiye.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  17. Species distribution and susceptibility profiles of oral candidiasis in hematological malignancy and solid tumor patients.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Francesca AmadoriDepartment of Medical and Surgical Specialities, Radiological Sciences and Public Health, Dental School, University of Brescia, P.le Spedali Civili 1, 25125, Brescia, Italy. francesca.amadori@unibs.it.
Elena BardelliniDepartment of Medical and Surgical Specialities, Radiological Sciences and Public Health, Dental School, University of Brescia, P.le Spedali Civili 1, 25125, Brescia, Italy.
Giulio ContiDepartment of Oral Surgery, University of Milan, IRCCS Ca' Granda, Ospedale Maggiore, Milan, Italy.
Nicola PedriniDepartment of Medical and Surgical Specialities, Radiological Sciences and Public Health, Dental School, University of Brescia, P.le Spedali Civili 1, 25125, Brescia, Italy.
Richard Fabian SchumacherPediatric Clinic-Department of Transplantation, AO Spedali Civili di Brescia-Italy, Brescia, Italy.
Alessandra MajoranaDepartment of Medical and Surgical Specialities, Radiological Sciences and Public Health, Dental School, University of Brescia, P.le Spedali Civili 1, 25125, Brescia, Italy.
University of Brescia · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to verify if low-level laser therapy could be useful to reduce chemotherapy-related oral mucositis grading and pain in childhood undergoing chemotherapy. A randomized double-blind clinical trial was carried out. Patients from 3 to 18 years of age undergoing cancer therapy and presenting OM grade 2 or more were eligible for this study. Patients were randomly divided in two groups: group A received laser therapy from the day of OM diagnosis and other 3 consecutive days (830 nm wavelength, power 150 mW, spot size 1 cm(2), 30 s per cm(2), energy density 4.5 J/cm(2)); group B received sham therapy (placebo) with the same timing. Two blind clinicians performed OM scoring and pain evaluation at day 1 (immediately before the beginning of laser treatment-T0), day 4 (after finishing laser therapy cycle-T1) and at day 7 (T2) as follow-up. A total of 123 patients were included in the study. Group A was composed of 62 children while group B is 61; in both groups, there was a progressive reduction in grade of OM, and at day 7, not every mucosal lesion disappeared. The difference in the decline of OM grading between the two groups resulted not statistically significant (p = 0.07). A statistically significant difference in pain reduction between two groups both at T1 and at T2 (p < 0.005) was observed. This study demonstrated the efficacy of LLLT in reducing pain due to chemotherapy-induced oral mucositis in children, while no significant benefit was noted in reducing OM grade.

Indexed as

AdolescentChildChild, PreschoolDouble-Blind MethodFemaleHumansLow-Level Light TherapyMalePainPain MeasurementStomatitisCancerChildrenLLLTMucositis

Identifiers

PMID27272517
OpenAlexW2409179383

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.