Evidence map›Paper›PMID 27272334›Full record

ReviewNutrition reviews2016

Safe use of high intakes of folic acid: research challenges and paths forward.

Abee L Boyles, Elizabeth A Yetley, Kristina A Thayer, Paul M Coates

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrition reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Abee L BoylesA.L. Boyles and K.A. Thayer are with the Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, North Carolina, USA. E.A. Yetley and P.M. Coates are with the Office of Dietary Supplements, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. abee.boyles@nih.gov.
Elizabeth A YetleyA.L. Boyles and K.A. Thayer are with the Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, North Carolina, USA. E.A. Yetley and P.M. Coates are with the Office of Dietary Supplements, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.
Kristina A ThayerA.L. Boyles and K.A. Thayer are with the Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, North Carolina, USA. E.A. Yetley and P.M. Coates are with the Office of Dietary Supplements, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.
Paul M CoatesA.L. Boyles and K.A. Thayer are with the Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, North Carolina, USA. E.A. Yetley and P.M. Coates are with the Office of Dietary Supplements, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.

Funding

Integrated Health Assessments for the National Toxicology ProgramZIAES103317 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ROONEY, ANDREW · 2016 to 2019
$24.4M
6 · The paper itself

Abstract

Adequate folic acid intake is an effective dietary-based prevention tool for reducing the risk of neural tube defects. Achieving adequate intake for the prevention of neural tube defects frequently requires the consumption of foods fortified with folic acid and/or the use of folic acid-containing dietary supplements. To date, research on the potential for adverse effects of high intakes of folic acid has been limited. Without such research, it is difficult to define a value for high intake. In May 2015, an expert panel was tasked with examining the available scientific literature and making research recommendations within 4 general categories of potential folate-related adverse health effects: cancer, cognition in conjunction with vitamin B12 deficiency, hypersensitivity-related outcomes, and thyroid and diabetes-related disorders. This article summarizes the expert panel's conclusions, outlines the challenges faced when reviewing the literature, and examines some of the panel's recommendations for research.

Indexed as

CognitionDiabetes ComplicationsDietary SupplementsFemaleFolic AcidFood, FortifiedHumansNeoplasmsNeural Tube DefectsResearchThyroid DiseasesVitamin B 12 DeficiencyFolic Acidfolic acidhigh vitamin intakeresearch recommendationssafety.

Identifiers

PMID27272334
PMCPMC5009460

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.