Evidence map›Paper›PMID 27272182›Full record

ArticleInternational journal of epidemiology2016

Trajectories of function and biomarkers with age: the CHS All Stars Study.

Anne B Newman, Jason L Sanders, Jorge R Kizer, Robert M Boudreau, Michelle C Odden, Adina Zeki Al Hazzouri, Alice M Arnold

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  16. Pace of Aging in older adults matters for healthspan and lifespan.medRxiv : the preprint server for health sciences · 2024
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anne B NewmanGraduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA newmana@edc.pitt.edu.
Jason L SandersHarvard Affiliated Emergency Medicine Residency, Massachusetts General Hospital, and Brigham and Women's Hospital Department of Emergency Medicine, Boston, MA, USA.
Jorge R KizerAlbert Einstein College of Medicine, Jack and Pearl Resnick Campus, Bronx, NY, USA.
Robert M BoudreauDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Michelle C OddenDepartment of Epidemiology, Oregon State University, Corvallis, OR, USA.
Adina Zeki Al HazzouriDepartment of Epidemiology, University of Miami, Miami, FL, USA.
Alice M ArnoldCollaborative Health Studies Coordinating Center, University of Washington, Seattle, WA, USA.

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHS Events Follow-up StudyR01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2009 to 2014
$6.3M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
Role of EIIIA fibronectin in pulmonary fibrosisR01HL085083 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WHITE, ERIC S · 2007 to 2011
$1.9M
Modeling Optimal Strategies to Prevent Cardiovascular Events in Older AdultsK01AG039387 · NIA · OREGON STATE UNIVERSITY · PI ODDEN, MICHELLE CHRISTINA · 2012 to 2016
$688k
CHS-Transition PhaseN01HC55222 · NHLBI · PI , · 2007 to 2007
$575k
NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS N01HC55222NHLBI NIH HHS N01HC85079NHLBI NIH HHS N01HC85080NHLBI NIH HHS N01HC85081NHLBI NIH HHS N01HC85082NHLBI NIH HHS N01HC85083NHLBI NIH HHS N01HC85086NHLBI NIH HHS R01 HL080295NHLBI NIH HHS U01 HL080295NIA NIH HHS K01 AG039387NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG023629
6 · The paper itself

Abstract

backgroundMultimorbidity is a major driver of physical and cognitive impairment, but rates of decline are also related to ageing. We sought to determine trajectories of decline in a large cohort by disease status, and examined their correspondence with biomarkers of ageing processes including growth hormone, sex steroid, inflammation, visceral adiposity and kidney function pathways.

methodsWe have followed the 5888 participants in the Cardiovascular Health Study (CHS) for healthy ageing and longevity since 1989-90. Gait speed, grip strength, modified mini-mental status examination (3MSE) and the digit symbol substitution test (DSST) were assessed annually to 1998-99 and again in 2005-06. Insulin-like growth hormone (IGF-1), dehydroepiandrosterone sulphate (DHEAS), interleukin-6 (IL-6), adiponectin and cystatin-C were assessed 3-5 times from stored samples. Health status was updated annually and dichotomized as healthy vs not healthy. Trajectories for each function measure and biomarker were estimated using generalized estimating equations as a function of age and health status using standardized values.

resultsTrajectories of functional decline showed strong age acceleration late in life in healthy older men and women as well as in chronically ill older adults. Adiponectin, IL-6 and cystatin-C tracked with functional decline in all domains; cystatin-C was consistently associated with functional declines independent of other biomarkers. DHEAS was independently associated with grip strength and IL-6 with grip strength and gait speed trajectories.

conclusionsFunctional decline in late life appears to mark a fundamental ageing process in that it occurred and was accelerated in late life regardless of health status. Cystatin C was most consistently associated with these functional declines.

Indexed as

CognitionGaitHand StrengthActivities of Daily LivingAdiponectinAgedAgingBiomarkersCohort StudiesCystatin CFemaleHealth StatusHumansInterleukin-6MaleNeuropsychological TestsAdiponectinBiomarkersCystatin CIL6 protein, humanInterleukin-6SomatomedinsAgeingbiomarkerscognitive functiondisabilitygait speedgrip strength

Identifiers

PMID27272182
PMCPMC5841627

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.