ArticleJournal of biomedical optics2016
Repeatability and reproducibility of optic nerve head perfusion measurements using optical coherence tomography angiography.
Article in Journal of biomedical optics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Review
- Quantitative analysis of macular and optic disc microvascular parameters in patients with immunoglobulin A nephropathy using optical coherence tomography angiography.Quantitative imaging in medicine and surgery · 2025Article
- Short-Wavelength Light-Blocking Filters and Oral Melatonin Administration in Patients With Retinitis Pigmentosa: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2023Article
- Diurnal change of retinal vessel density related to hemodynamic variation in treatment-naïve low-teens normal-tension glaucoma.Scientific reports · 2023Article
- Article
- Thinner Central Corneal Thickness is Associated with a Decreased Parapapillary Vessel Density in Normal Tension Glaucoma.Journal of ophthalmology · 2022Article
- Repeatability of Peripapillary OCT Angiography in Neurodegenerative Disease.Ophthalmology science · 2021Article
- Current and novel multi-imaging modalities to assess retinal oxygenation and blood flow.Eye (London, England) · 2021Review
- Effect of systemic blood pressure on optical coherence tomography angiography in glaucoma patients.Eye (London, England) · 2021Article
- Past, present and future role of retinal imaging in neurodegenerative disease.Progress in retinal and eye research · 2021Review
- Association between risk factors and retinal nerve fiber layer loss in early stages of diabetic retinopathy.International journal of ophthalmology · 2021Article
- Article
- Altered visual functions, macular ganglion cell and papillary retinal nerve fiber layer thickness in early-treated adult PKU patients.Molecular genetics and metabolism reports · 2020Article
- Diurnal fluctuations of macular vessel density in patients with primary open-angle glaucoma and healthy subjects.International ophthalmology · 2020Article
- Functional and Structural Reliability of Optic Nerve Head Measurements in Healthy Eyes by Means of Optical Coherence Tomography Angiography.Medicina (Kaunas, Lithuania) · 2020Observational
- Peripapillary Region Perfusion and Retinal Nerve Fiber Layer Thickness Abnormalities in Diabetic Retinopathy Assessed by OCT Angiography.Translational vision science & technology · 2019Article
- Effect of Scan Size on Glaucoma Diagnostic Performance Using OCT Angiography En Face Images of the Radial Peripapillary Capillaries.Journal of glaucoma · 2019Observational
- Quantification and Repeatability of Vessel Density and Flux as Assessed by Optical Coherence Tomography Angiography.Translational vision science & technology · 2019Article
- Optic Nerve Head Perfusion Before and After Intravitreal Antivascular Growth Factor Injections Using Optical Coherence Tomography-based Microangiography.Journal of glaucoma · 2019Article
- Comparison of the Repeatability of Macular Vascular Density Measurements Using Four Optical Coherence Tomography Angiography Systems.Journal of ophthalmology · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Optical coherence tomography angiography (OCTA) has increasingly become a clinically useful technique in ophthalmic imaging. We evaluate the repeatability and reproducibility of blood perfusion in the optic nerve head (ONH) measured using optical microangiography (OMAG)-based OCTA. Ten eyes from 10 healthy volunteers are recruited and scanned three times with a 68-kHz Cirrus HD-OCT 5000-based OMAG prototype system (Carl Zeiss Meditec Inc., Dublin, California) centered at the ONH involving two separate visits within six weeks. Vascular images are generated with OMAG processing by detecting the differences in OCT signals between consecutive B-scans acquired at the same retina location. ONH perfusion is quantified as flux, vessel area density, and normalized flux within the ONH for the prelaminar, lamina cribrosa, and the full ONH. Coefficient of variation (CV) and intraclass correlation coefficient (ICC) are used to evaluate intravisit and intervisit repeatability, and interobserver reproducibility. ONH perfusion measurements show high repeatability [CV≤3.7% (intravisit) and ≤5.2% (intervisit)] and interobserver reproducibility (ICC≤0.966) in all three layers by three metrics. OCTA provides a noninvasive method to visualize and quantify ONH perfusion in human eyes with excellent repeatability and reproducibility, which may add additional insight into ONH perfusion in clinical practice.
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