Evidence map›Paper›PMID 27272025›Full record

ArticleScientific reports2016

Population structure of eleven Spanish ovine breeds and detection of selective sweeps with BayeScan and hapFLK.

A Manunza, T F Cardoso, A Noce, A Martínez, A Pons, L A Bermejo, V Landi, A Sànchez, J Jordana, J V Delgado and 8 more

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

A ManunzaDepartment of Animal Genetics, Center for Research in Agricultural Genomics (CSIC-IRTA-UAB-UB), Campus Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.
T F CardosoDepartment of Animal Genetics, Center for Research in Agricultural Genomics (CSIC-IRTA-UAB-UB), Campus Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.
A NoceDepartment of Animal Genetics, Center for Research in Agricultural Genomics (CSIC-IRTA-UAB-UB), Campus Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.
A MartínezDepartamento de Genética, Universidad de Córdoba, Córdoba 14071, Spain.
A PonsUnitat de Races Autòctones, Servei de Millora Agrària i Pesquera (SEMILLA), Son Ferriol 07198, Spain.
L A BermejoDepartamento de Ingeniería, Producción y Economía Agrarias, Universidad de La Laguna, 38071 La Laguna, Tenerife, Spain.
V LandiDepartamento de Genética, Universidad de Córdoba, Córdoba 14071, Spain.
A SànchezDepartment of Animal Genetics, Center for Research in Agricultural Genomics (CSIC-IRTA-UAB-UB), Campus Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.
J JordanaDepartament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.
J V DelgadoDepartamento de Genética, Universidad de Córdoba, Córdoba 14071, Spain.
S AdánFederación de Razas Autóctonas de Galicia (BOAGA), Pazo de Fontefiz, 32152 Coles. Ourense, Spain.
J CapoteInstituto Canario de Investigaciones Agrarias, La Laguna 38108, Tenerife, Spain.
O VidalDepartament de Biologia, Universitat de Girona, Girona 17071, Spain.
E UgarteNeiker-Tecnalia, Campus Agroalimentario de Arkaute, apdo 46 E-01080 Vitoria-Gazteiz (Araba), Spain.
J J ArranzDepartamento de Producción Animal, Universidad de León, León 24071, Spain.
J H CalvoCentro de Investigación y Tecnología Agroalimentaria de Aragón (CITA), Unidad de Tecnología en Producción Animal, Avda. Montañana, 930, 50059 Zaragoza, Spain.
J CasellasDepartament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.
M AmillsDepartment of Animal Genetics, Center for Research in Agricultural Genomics (CSIC-IRTA-UAB-UB), Campus Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The goals of the current work were to analyse the population structure of 11 Spanish ovine breeds and to detect genomic regions that may have been targeted by selection. A total of 141 individuals were genotyped with the Infinium 50 K Ovine SNP BeadChip (Illumina). We combined this dataset with Spanish ovine data previously reported by the International Sheep Genomics Consortium (N = 229). Multidimensional scaling and Admixture analyses revealed that Canaria de Pelo and, to a lesser extent, Roja Mallorquina, Latxa and Churra are clearly differentiated populations, while the remaining seven breeds (Ojalada, Castellana, Gallega, Xisqueta, Ripollesa, Rasa Aragonesa and Segureña) share a similar genetic background. Performance of a genome scan with BayeScan and hapFLK allowed us identifying three genomic regions that are consistently detected with both methods i.e. Oar3 (150-154 Mb), Oar6 (4-49 Mb) and Oar13 (68-74 Mb). Neighbor-joining trees based on polymorphisms mapping to these three selective sweeps did not show a clustering of breeds according to their predominant productive specialization (except the local tree based on Oar13 SNPs). Such cryptic signatures of selection have been also found in the bovine genome, posing a considerable challenge to understand the biological consequences of artificial selection.

Indexed as

Genetics, PopulationGenetic VariationSelection, GeneticAnimalsCluster AnalysisGenotypeGenotyping TechniquesSheepSpain

Identifiers

PMID27272025
PMCPMC4895181

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.