ArticlePhysics in medicine and biology2016
Simulations on the influence of myelin water in diffusion-weighted imaging.
Article in Physics in medicine and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Validating the standard model of diffusion MRI in white matter with numerical substrates.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Multiparametric MRI Can Detect Enhanced Myelination in the Ex Vivo Gli1NMR in biomedicine · 2025Article
- CNS Embryonal Tumor with PLAGL Amplification, a New Tumor in Children and Adolescents: Insights from a Comprehensive MRI Analysis.AJNR. American journal of neuroradiology · 2025Article
- Predicting Mesoscopic Larmor Frequency Shifts in White Matter With Diffusion MRI-A Monte Carlo Study in Axonal Phantoms.NMR in biomedicine · 2025Article
- TJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- A simple estimate of axon size with diffusion MRI.NeuroImage · 2021Article
- Realistic Microstructure Simulator (RMS): Monte Carlo simulations of diffusion in three-dimensional cell segmentations of microscopy images.Journal of neuroscience methods · 2021Article
- Challenges in diffusion MRI tractography - Lessons learned from international benchmark competitions.Magnetic resonance imaging · 2019Review
- Towards microstructure fingerprinting: Estimation of tissue properties from a dictionary of Monte Carlo diffusion MRI simulations.NeuroImage · 2019Article
- Standardization of T1w/T2w Ratio Improves Detection of Tissue Damage in Multiple Sclerosis.Frontiers in neurology · 2019Article
- White matter intercompartmental water exchange rates determined from detailed modeling of the myelin sheath.Magnetic resonance in medicine · 2019Article
- Physical and numerical phantoms for the validation of brain microstructural MRI: A cookbook.NeuroImage · 2018Review
- Diffusional kurtosis imaging and white matter microstructure modeling in a clinical study of major depressive disorder.NMR in biomedicine · 2018Article
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2 authors.
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Abstract
While myelinated axons present an important barrier to water diffusion, many models used to interpret DWI signal neglect other potential influences of myelin. In this work, Monte Carlo simulations were used to test the sensitivity of DWI results to the diffusive properties of water within myelin. Within these simulations, the apparent diffusion coefficient (D app) varied slowly over several orders of magnitude of the coefficient of myelin water diffusion (D m), but exhibited important differences compared to D app values simulated that neglect D m (=0). Compared to D app, the apparent diffusion kurtosis (K app) was generally more sensitive to D m. Simulations also tested the sensitivity of D app and K app to the amount of myelin present. Unique variations in D app and K app caused by differences in the myelin volume fraction were diminished when myelin water diffusion was included. Also, expected trends in D app and K app with experimental echo time were reduced or inverted when accounting for myelin water diffusion, and these reduced/inverted trends were seen experimentally in ex vivo rat brain DWI experiments. In general, myelin water has the potential to subtly influence DWI results and bias models of DWI that neglect these components of white matter.
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