Evidence map›Paper›PMID 27271855›Full record

ArticleTranslational psychiatry2016

Higher reward value of starvation imagery in anorexia nervosa and association with the Val66Met BDNF polymorphism.

J Clarke, N Ramoz, A-K Fladung, P Gorwood

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
11.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Momentary physiological indices related to eating disorders: A systematic and methodological review.European eating disorders review : the journal of the Eating Disorders Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

J ClarkeClinique des Maladies Mentales et de l'Encéphale (CMME), Hospital Sainte-Anne, Paris-Descartes University, Paris, France.
N RamozClinique des Maladies Mentales et de l'Encéphale (CMME), Hospital Sainte-Anne, Paris-Descartes University, Paris, France.
A-K FladungDepartment of Psychiatry and Psychotherapy, University of Ulm, Ulm, Germany.
P GorwoodClinique des Maladies Mentales et de l'Encéphale (CMME), Hospital Sainte-Anne, Paris-Descartes University, Paris, France.
Inserm · FRInstitut de Psychiatrie et Neurosciences de Paris · FRUniversität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies support the idea that abnormalities of the reward system contribute to onset and maintenance of anorexia nervosa (AN). Next to cues coding for overweight, other research suggest cues triggering the proposed starvation dependence to be pivotally involved in the AN pathogenesis. We assessed the characteristics of the cognitive, emotional and physiologic response toward disease-specific pictures of female body shapes, in adult AN patients compared with healthy control (HC) women. Frequency and amplitude of skin conductance response (SCR) in 71 patients with AN and 20 HC were registered during processing of stimuli of three weight categories (over-, under- and normal weight). We then assessed the role of the Val66Met BDNF polymorphism as a potential intermediate factor. AN patients reported more positive feelings during processing of underweight stimuli and more negative feelings for normal- and overweight stimuli. The SCR showed a group effect (P=0.007), AN patients showing overall higher frequency of the response. SCR within patients was more frequent during processing of underweight stimuli compared with normal- and overweight stimuli. The Met allele of the BDNF gene was not more frequent in patients compared with controls, but was associated to an increased frequency of SCR (P=0.008) in response to cues for starvation. A higher positive value of starvation, rather than more negative one of overweight, might more accurately define females with AN. The Met allele of the BDNF gene could partly mediate the higher reward value of starvation observed in AN.

Indexed as

AllelesBody WeightImaginationRewardAdultAnorexia NervosaBrain-Derived Neurotrophic FactorCuesFemaleHumansOverweightPolymorphism, GeneticReference ValuesStarvationBDNF protein, humanBrain-Derived Neurotrophic Factor

Identifiers

PMID27271855
PMCPMC4931615
OpenAlexW2418640704

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.