ArticleInfection and immunity2016
Investigating the Relatedness of Enteroinvasive Escherichia coli to Other E. coli and Shigella Isolates by Using Comparative Genomics.
Article in Infection and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Impact of Biannual Mass Azithromycin Treatment on Enteropathogen Carriage in Children <5 Years Old in Niger.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Trial
- Epidemiology of Single-Etiology Non-Shiga Toxin-ProducingFood protection trends · 2026Article
- First recorded food-borne outbreak of gastroenteritis caused by enteroinvasive Escherichia coli serotype O8:H19 in Thailand.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Shigella and childhood stunting: Evidence, gaps, and future research directions.PLoS neglected tropical diseases · 2023Review
- ShigaPass: anMicrobial genomics · 2023Article
- Genomics and pathotypes of the many faces of Escherichia coli.FEMS microbiology reviews · 2022Article
- Cluster-specific gene markers enhanceMicrobial genomics · 2021Article
- Draft Genome Sequences of Two Enteroinvasive Escherichia coli Strains Representative of Major EnteroinvasiveMicrobiology resource announcements · 2021Article
- A One Health Perspective for Defining and DecipheringComparative medicine · 2021Review
- The population genetics of pathogenic Escherichia coli.Nature reviews. Microbiology · 2021Review
- Phylogenetic background and habitat drive the genetic diversification of Escherichia coli.PLoS genetics · 2020Article
- A Multifactorial Approach for Surveillance ofFrontiers in microbiology · 2020Article
- Virulence-Related Gene Distribution AmongInfection and drug resistance · 2020Article
- Incidence, clinical implications and impact on public health of infections with Shigella spp. and entero-invasive Escherichia coli (EIEC): results of a multicenter cross-sectional study in the Netherlands during 2016-2017.BMC infectious diseases · 2019Article
- Laboratory Cultivation and Storage of Shigella.Current protocols in microbiology · 2019Article
- The Complete Genome of the Atypical Enteropathogenic Escherichia coli Archetype Isolate E110019 Highlights a Role for Plasmids in Dissemination of the Type III Secreted Effector EspT.Infection and immunity · 2019Article
- Shifting national surveillance of Shigella infections toward geno-serotyping by the development of a tailored Luminex assay and NGS workflow.MicrobiologyOpen · 2019Article
- Existence of virulence genes in clinicalAnnals of translational medicine · 2019Article
- The Autotransporter IcsA Promotes Shigella flexneri Biofilm Formation in the Presence of Bile Salts.Infection and immunity · 2019Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Enteroinvasive Escherichia coli (EIEC) is a unique pathovar that has a pathogenic mechanism nearly indistinguishable from that of Shigella species. In contrast to isolates of the four Shigella species, which are widespread and can be frequent causes of human illness, EIEC causes far fewer reported illnesses each year. In this study, we analyzed the genome sequences of 20 EIEC isolates, including 14 first described in this study. Phylogenomic analysis of the EIEC genomes demonstrated that 17 of the isolates are present in three distinct lineages that contained only EIEC genomes, compared to reference genomes from each of the E. coli pathovars and Shigella species. Comparative genomic analysis identified genes that were unique to each of the three identified EIEC lineages. While many of the EIEC lineage-specific genes have unknown functions, those with predicted functions included a colicin and putative proteins involved in transcriptional regulation or carbohydrate metabolism. In silico detection of the Shigella virulence plasmid (pINV), which is essential for the invasion of host cells, demonstrated that a form of pINV was present in nearly all EIEC genomes, but the Mxi-Spa-Ipa region of the plasmid that encodes the invasion-associated proteins was absent from several of the EIEC isolates. The comparative genomic findings in this study support the hypothesis that multiple EIEC lineages have evolved independently from multiple distinct lineages of E. coli via the acquisition of the Shigella virulence plasmid and, in some cases, the Shigella pathogenicity islands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.