ArticleNutrients2016
Marginal Ascorbate Status (Hypovitaminosis C) Results in an Attenuated Response to Vitamin C Supplementation.
Article in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Vitamin C demand is increased after total knee arthroplasty: a double-blind placebo-controlled-randomized study.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Trial
- Relationship Between Hypovitaminosis C, Obesity, and Features of Metabolic Syndrome-A Narrative Review.Nutrition reviews · 2026Review
- Serum Vitamin C concentrations are inversely related to biological aging: a population-based cross-sectional study.European journal of medical research · 2025Article
- A Systematized Review of the Relationship Between Obesity and Vitamin C Requirements.Current developments in nutrition · 2024Review
- A High Vitamin C Micronutrient Supplement Is Unable to Attenuate Inflammation in People with Metabolic Syndrome but May Improve Metabolic Health Indices: A Randomised Controlled Trial.Antioxidants (Basel, Switzerland) · 2024Article
- What We Are Missing: Using Machine Learning Models to Predict Vitamin C Deficiency in Patients with Metabolic and Bariatric Surgery.Obesity surgery · 2023Article
- Subclinical Vitamin C Plasma Levels Associated with Increased Risk of CAD Diagnosis via Inflammation: Results from the NHANES 2003-2006 Surveys.Nutrients · 2023Article
- Supplementation with Oral Vitamin C Prior to and during Myeloablative Chemotherapy and Autologous Haematopoietic Stem Cell Transplantation: A Pilot Study.Antioxidants (Basel, Switzerland) · 2022Article
- Estimation of Vitamin C Intake Requirements Based on Body Weight: Implications for Obesity.Nutrients · 2022Article
- Vitamin C Plasma Levels Associated with Inflammatory Biomarkers, CRP and RDW: Results from the NHANES 2003-2006 Surveys.Nutrients · 2022Article
- Vitamin C Status in People with Types 1 and 2 Diabetes Mellitus and Varying Degrees of Renal Dysfunction: Relationship to Body Weight.Antioxidants (Basel, Switzerland) · 2022Article
- Micronutrient Deficiency as a Confounder in Ascertaining the Role of Obesity in Severe COVID-19 Infection.International journal of environmental research and public health · 2022Review
- Dual colorimetric sensing of ascorbic acid and thyroxine using Ag-EGCG-CTABRSC advances · 2021Article
- Insufficient Vitamin C Levels among Adults in the United States: Results from the NHANES Surveys, 2003-2006.Nutrients · 2021Article
- Article
- Factors Affecting Vitamin C Status and Prevalence of Deficiency: A Global Health Perspective.Nutrients · 2020Review
- On the effect of vitamin C intake on human health: How to (mis)interprete the clinical evidence.Redox biology · 2020Review
- Vitamin C: A Review on its Role in the Management of Metabolic Syndrome.International journal of medical sciences · 2020Review
- The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome.Redox biology · 2019Review
- Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes.Critical care (London, England) · 2017Observational
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inadequate dietary intake of vitamin C results in hypovitaminosis C, defined as a plasma ascorbate concentration ≤23 μmol/L. Our objective was to carry out a retrospective analysis of two vitamin C supplementation studies to determine whether supplementation with 50 mg/day vitamin C is sufficient to restore adequate ascorbate status (≥50 μmol/L) in individuals with hypovitaminosis C. Plasma ascorbate data from 70 young adult males, supplemented with 50 or 200 mg/day vitamin C for up to six weeks, was analyzed. Hypovitaminosis C status was identified based on plasma ascorbate being ≤23 μmol/L and the response of these individuals to vitamin C supplementation was examined. Of the participants consuming 50 mg/day vitamin C for up to six weeks, those with hypovitaminosis C at baseline achieved plasma concentrations of only ~30 μmol/L, whereas the remainder reached ~50 μmol/L. Participants who consumed 200 mg/day vitamin C typically reached saturating concentrations (>65 μmol/L) within one week, while those with hypovitaminosis C required two weeks to reach saturation. Regression modelling indicated that the participants' initial ascorbate status and body weight explained ~30% of the variability in the final ascorbate concentration. Overall, our analysis revealed that supplementation with 50 mg/day vitamin C, which resulted in a total dietary vitamin C intake of 75 mg/day, was insufficient to achieve adequate plasma ascorbate concentrations in individuals with hypovitaminosis C. Furthermore, increased body weight had a negative impact on ascorbate status.
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Registered trials
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