ArticleMarine drugs2016
Identification of Angiotensin I-Converting Enzyme Inhibitory Peptides Derived from Enzymatic Hydrolysates of Razor Clam Sinonovacula constricta.
Article in Marine drugs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Identification, Characterization and Multi-Target Mechanism of Novel ACE Inhibitory Peptides fromMolecules (Basel, Switzerland) · 2026Article
- Impact ofFoods (Basel, Switzerland) · 2026Article
- From Multi-Species Screening to Targeted Investigation: Discovery of ACE Inhibitory Peptides inMolecules (Basel, Switzerland) · 2026Article
- The first bioactive (angiotensin-converting enzyme-inhibitory) peptide isolated from pearl matrix protein.Heliyon · 2024Article
- Porcine Intestinal Mucosal Peptides Target Macrophage-Modulated Inflammation and Alleviate Intestinal Homeostasis in Dextrose Sodium Sulfate-Induced Colitis in Mice.Foods (Basel, Switzerland) · 2024Article
- Purification and Molecular Docking Study on the Angiotensin I-Converting Enzyme (ACE)-Inhibitory Peptide Isolated from Hydrolysates of the Deep-Sea MusselMarine drugs · 2023Article
- Article
- Current Trends of Bioactive Peptides-New Sources and Therapeutic Effect.Foods (Basel, Switzerland) · 2020Review
- Article
- Overview on the Antihypertensive and Anti-Obesity Effects of Secondary Metabolites from Seaweeds.Marine drugs · 2018Review
- Production of antioxidant and ACE-inhibitory peptides from Kluyveromyces marxianus protein hydrolysates: Purification and molecular docking.Journal of food and drug analysis · 2018Article
- Phylogenetic Status of Two Undescribed Zygomycete Species from Korea:Mycobiology · 2017Article
- Peptides, Peptidomimetics, and Polypeptides from Marine Sources: A Wealth of Natural Sources for Pharmaceutical Applications.Marine drugs · 2017Review
- Production and characterization of functional properties of protein hydrolysates from egg shell membranes by lactic acid bacteria fermentation.Journal of food science and technology · 2017Article
- Optimization of Bromelain-Aided Production of Angiotensin I-Converting Enzyme Inhibitory Hydrolysates from Stone Fish Using Response Surface Methodology.Marine drugs · 2017Article
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Authors and funding
6 authors.
Funding
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Abstract
Angiotensin I-converting enzyme (ACE) inhibitory activity of razor clam hydrolysates produced using five proteases, namely, pepsin, trypsin, alcalase, flavourzyme and proteases from Actinomucor elegans T3 was investigated. Flavourzyme hydrolysate showed the highest level of degree of hydrolysis (DH) (45.87%) followed by A. elegans T3 proteases hydrolysate (37.84%) and alcalase (30.55%). The A. elegans T3 proteases was observed to be more effective in generating small peptides with ACE-inhibitory activity. The 3 kDa membrane permeate of A. elegans T3 proteases hydrolysate showed the highest ACE-inhibitory activity with an IC50 of 0.79 mg/mL. After chromatographic separation by Sephadex G-15 gel filtration and reverse phase-high performance liquid chromatography, the potent fraction was subjected to MALDI/TOF-TOF MS/MS for identification. A novel ACE-inhibitory peptide (VQY) was identified exhibiting an IC50 of 9.8 μM. The inhibitory kinetics investigation by Lineweaver-Burk plots demonstrated that the peptide acts as a competitive ACE inhibitor. The razor clam hydrolysate obtained by A. elegans T3 proteases could serve as a source of functional peptides with ACE-inhibitory activity for physiological benefits.
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