ReviewCurrent heart failure reports2016
Dietary Nitrate and Skeletal Muscle Contractile Function in Heart Failure.
Review in Current heart failure reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dietary Nitrate and Muscle Power With Aging
Dose-response Effect of Dietary Nitrate on Muscle Function in Older Individuals
Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Effects of Beetroot Juice Ingestion on Physical Performance in Highly Competitive Tennis Players.Nutrients · 2020Trial
- Trial
- Dietary Nitrate Increases VOJournal of cardiac failure · 2018Trial
- Dietary nitrate does not modify blood pressure and cardiac output at rest and during exercise in older adults: a randomised cross-over study.International journal of food sciences and nutrition · 2018Trial
- Effect of acute dietary nitrate intake on post-activation performance enhancement in male long jumpers.Frontiers in nutrition · 2026Article
- The role of vascular function on exercise capacity in health and disease.The Journal of physiology · 2021Review
- Nitric oxide enhancement supplement containing beet nitrite and nitrate benefits high intensity cycle interval training.Current research in physiology · 2021Article
- Edward F. Adolph Distinguished Lecture. Contemporary model of muscle microcirculation: gateway to function and dysfunction.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Review
- Dietary Nitrate Enhances the Contractile Properties of Human Skeletal Muscle.Exercise and sport sciences reviews · 2018Review
- Does nutrition play a role in the prevention and management of sarcopenia?Clinical nutrition (Edinburgh, Scotland) · 2018Review
- Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health.Free radical biology & medicine · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Heart failure (HF) patients suffer from exercise intolerance that diminishes their ability to perform normal activities of daily living and hence compromises their quality of life. This is due largely to detrimental changes in skeletal muscle mass, structure, metabolism, and function. This includes an impairment of muscle contractile performance, i.e., a decline in the maximal force, speed, and power of muscle shortening. Although numerous mechanisms underlie this reduction in contractility, one contributing factor may be a decrease in nitric oxide (NO) bioavailability. Consistent with this, recent data demonstrate that acute ingestion of NO3 (-)-rich beetroot juice, a source of NO via the NO synthase-independent enterosalivary pathway, markedly increases maximal muscle speed and power in HF patients. This review discusses the role of muscle contractile dysfunction in the exercise intolerance characteristic of HF, and the evidence that dietary NO3 (-) supplementation may represent a novel and simple therapy for this currently underappreciated problem.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.