ArticleMolecular plant pathology2016
Dispensable chromosomes in Fusarium oxysporum f. sp. lycopersici.
Article in Molecular plant pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 114 citations in OpenAlex.
- Pathogenicity and Virulence ofVirulence · 2026Review
- Virulence determinants of Fusarium oxysporum for clinical infections.PLoS pathogens · 2026Article
- A chromosome-level genome assembly of the Fusarium oxysporum biocontrol strain FO12.Scientific data · 2026Article
- The dual nature ofFrontiers in microbiology · 2026Review
- Horizontal Chromosome Transfer between Pathogenic and Non-pathogenic Fusarium oxysporum Strains Isolated from Cabbage.Microbes and environments · 2026Article
- Holistic genome assembly and analysis of theIMA fungus · 2026Article
- Frequent genetic exchanges revealed by a pan-mitogenome graph of a fungal plant pathogen.mBio · 2024Article
- Comparative genomics and transcriptomics reveal differences in effector complement and expression between races ofFrontiers in plant science · 2024Article
- A conceptual framework for nomenclatural stability and validity of medically important fungi: a proposed global consensus guideline for fungal name changes supported by ABP, ASM, CLSI, ECMM, ESCMID-EFISG, EUCAST-AFST, FDLC, IDSA, ISHAM, MMSA, and MSGERC.Journal of clinical microbiology · 2023Article
- Chromosome-scale assembly uncovers genomic compartmentation ofFrontiers in microbiology · 2023Article
- Genome editing using a versatile vector-based CRISPR/Cas9 system in Fusarium species.Scientific reports · 2022Article
- Comparative genomics of host-specialized populations ofFrontiers in fungal biology · 2022Article
- Differentiation of the Pea Wilt Pathogen Fusarium oxysporum f. sp. pisi from Other Isolates of Fusarium Species by PCR.Microbes and environments · 2022Article
- Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus.Nature communications · 2021Article
- Metatranscriptomic Comparison of Endophytic and PathogenicMolecular plant-microbe interactions : MPMI · 2021Article
- A pair of effectors encoded on a conditionally dispensable chromosome of Fusarium oxysporum suppress host-specific immunity.Communications biology · 2021Article
- Genome-wide mapping of histone modifications during axenic growth in two species of Leptosphaeria maculans showing contrasting genomic organization.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2021Article
- A single gene in Fusarium oxysporum limits host range.Molecular plant pathology · 2021Article
- Accessory Chromosome-Acquired Secondary Metabolism in Plant Pathogenic Fungi: The Evolution of Biotrophs Into Host-Specific Pathogens.Frontiers in microbiology · 2021Review
- Secreted in Xylem Genes: Drivers of Host Adaptation inFrontiers in plant science · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genomes of many filamentous fungi consist of a 'core' part containing conserved genes essential for normal development as well as conditionally dispensable (CD) or lineage-specific (LS) chromosomes. In the plant-pathogenic fungus Fusarium oxysporum f. sp. lycopersici, one LS chromosome harbours effector genes that contribute to pathogenicity. We employed flow cytometry to select for events of spontaneous (partial) loss of either the two smallest LS chromosomes or two different core chromosomes. We determined the rate of spontaneous loss of the 'effector' LS chromosome in vitro at around 1 in 35 000 spores. In addition, a viable strain was obtained lacking chromosome 12, which is considered to be a part of the core genome. We also isolated strains carrying approximately 1-Mb deletions in the LS chromosomes and in the dispensable core chromosome. The large core chromosome 1 was never observed to sustain deletions over 200 kb. Whole-genome sequencing revealed that some of the sites at which the deletions occurred were the same in several independent strains obtained for the two chromosomes tested, indicating the existence of deletion hotspots. For the core chromosome, this deletion hotspot was the site of insertion of the marker used to select for loss events. Loss of the core chromosome did not affect pathogenicity, whereas loss of the effector chromosome led to a complete loss of pathogenicity.
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