Evidence map›Paper›PMID 27271309›Full record

ArticleHypertension (Dallas, Tex. : 1979)2016

Genome-Wide Gene-Sodium Interaction Analyses on Blood Pressure: The Genetic Epidemiology Network of Salt-Sensitivity Study.

Changwei Li, Jiang He, Jing Chen, Jinying Zhao, Dongfeng Gu, James E Hixson, Dabeeru C Rao, Cashell E Jaquish, Charles C Gu, Jichun Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Guideline
  2. Pooled it
  3. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019
    Guideline
  4. Pooled it
  5. Clinical implementation of polygenic risk scores based on GWAS in the management of hypertension among Asian populations.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  6. Observational
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Genetics of Hypertension: From Monogenic Analysis to GETomics.Journal of cardiovascular development and disease · 2024
    Review
  14. Long Noncoding RNA MALAT1: Salt-Sensitive Hypertension.International journal of molecular sciences · 2024
    Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Changwei LiFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G., J.C., J.H., S.C.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., C.C.G.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Jiang HeFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G., J.C., J.H., S.C.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., C.C.G.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Jing ChenFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G., J.C., J.H., S.C.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., C.C.G.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Jinying ZhaoFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G., J.C., J.H., S.C.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., C.C.G.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Dongfeng GuFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G., J.C., J.H., S.C.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., C.C.G.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
James E HixsonFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G., J.C., J.H., S.C.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., C.C.G.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Dabeeru C RaoFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G., J.C., J.H., S.C.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., C.C.G.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Cashell E JaquishFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G., J.C., J.H., S.C.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., C.C.G.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Charles C GuFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G., J.C., J.H., S.C.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., C.C.G.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Jichun ChenFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G., J.C., J.H., S.C.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., C.C.G.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Jianfeng HuangFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G., J.C., J.H., S.C.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., C.C.G.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Shufeng ChenFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G., J.C., J.H., S.C.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., C.C.G.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Tanika N KellyFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G., J.C., J.H., S.C.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., C.C.G.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.). tkelly@tulane.edu.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Genetic Epidemiology of Blood Pressure InterventionU01HL072507 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2002 to 2008
$7.6M
Family-Based Genome-wide Association Study for Salt-Sensitivity of Blood PressureR01HL090682 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2008 to 2011
$2.8M
Sodium Sensitivity and Risk of HypertensionR01HL087263 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2007 to 2011
$2.8M
Cigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
SLEEP AND ENTRAINMENT OF SCN FUNCTIONR01HL064278 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI STROHL, KINGMAN PERKINS · 1999 to 2002
$871k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592k
NCRR NIH HHS UL1 RR024156NHLBI NIH HHS K08 HL091108NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R01 HL087263NHLBI NIH HHS R01 HL090682NHLBI NIH HHS U01 HL072507
6 · The paper itself

Abstract

We performed genome-wide analyses to identify genomic loci that interact with sodium to influence blood pressure (BP) using single-marker-based (1 and 2 df joint tests) and gene-based tests among 1876 Chinese participants of the Genetic Epidemiology Network of Salt-Sensitivity (GenSalt) study. Among GenSalt participants, the average of 3 urine samples was used to estimate sodium excretion. Nine BP measurements were taken using a random zero sphygmomanometer. A total of 2.05 million single-nucleotide polymorphisms were imputed using Affymetrix 6.0 genotype data and the Chinese Han of Beijing and Japanese of Tokyo HapMap reference panel. Promising findings (P<1.00×10(-4)) from GenSalt were evaluated for replication among 775 Chinese participants of the Multi-Ethnic Study of Atherosclerosis (MESA). Single-nucleotide polymorphism and gene-based results were meta-analyzed across the GenSalt and MESA studies to determine genome-wide significance. The 1 df tests identified interactions for UST rs13211840 on diastolic BP (P=3.13×10(-9)). The 2 df tests additionally identified associations for CLGN rs2567241 (P=3.90×10(-12)) and LOC105369882 rs11104632 (P=4.51×10(-8)) with systolic BP. The CLGN variant rs2567241 was also associated with diastolic BP (P=3.11×10(-22)) and mean arterial pressure (P=2.86×10(-15)). Genome-wide gene-based analysis identified MKNK1 (P=6.70×10(-7)), C2orf80 (P<1.00×10(-12)), EPHA6 (P=2.88×10(-7)), SCOC-AS1 (P=4.35×10(-14)), SCOC (P=6.46×10(-11)), CLGN (P=3.68×10(-13)), MGAT4D (P=4.73×10(-11)), ARHGAP42 (P≤1.00×10(-12)), CASP4 (P=1.31×10(-8)), and LINC01478 (P=6.75×10(-10)) that were associated with at least 1 BP phenotype. In summary, we identified 8 novel and 1 previously reported BP loci through the examination of single-nucleotide polymorphism and gene-based interactions with sodium.

Indexed as

HypertensionSodium ChlorideADP-Ribosylation FactorsAdultBlood PressureBlood Pressure DeterminationCalcium-Binding ProteinsCaspases, InitiatorChinaFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansIntracellular Signaling Peptides and ProteinsMaleMiddle AgedADP-Ribosylation FactorsARL6 protein, humanCalcium-Binding ProteinscalmeginCASP4 protein, humanCaspases, InitiatorIntracellular Signaling Peptides and ProteinsMKNK1 protein, humanMolecular ChaperonesProtein Serine-Threonine KinasesSodium Chlorideblood pressuregenesgenome-wide association studysodium

Identifiers

PMID27271309
PMCPMC5373034

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.