Evidence map›Paper›PMID 27271290›Full record

ArticlePloS one2016

Limited Genetic Diversity of Hepatitis B Virus in the General Population of the Offin River Valley in Ghana.

Kobina Assan Ampah, Carlos Augusto Pinho-Nascimento, Sarah Kerber, Prince Asare, Daniel De-Graft, Frank Adu-Nti, Izabel C N P Paixão, Christian Niel, Dorothy Yeboah-Manu, Gerd Pluschke and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. The status of hepatitis B control in the African region.The Pan African medical journal · 2017
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Kobina Assan AmpahSwiss Tropical and Public Health Institute, Molecular Immunology, Basel, Switzerland.
Carlos Augusto Pinho-NascimentoLaboratory of Molecular Virology, Biology Institute, Fluminense Federal University, Niterói, Brazil.
Sarah KerberSwiss Tropical and Public Health Institute, Molecular Immunology, Basel, Switzerland.
Prince AsareNoguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Daniel De-GraftNoguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Frank Adu-NtiRadford University College, Accra, Ghana.
Izabel C N P PaixãoLaboratory of Molecular Virology, Biology Institute, Fluminense Federal University, Niterói, Brazil.
Christian NielLaboratory of Molecular Virology, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
Dorothy Yeboah-ManuNoguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Gerd PluschkeSwiss Tropical and Public Health Institute, Molecular Immunology, Basel, Switzerland.
Katharina RöltgenSwiss Tropical and Public Health Institute, Molecular Immunology, Basel, Switzerland.
Noguchi Memorial Institute for Medical Research · GHSwiss Tropical and Public Health Institute · CHUniversidade Federal Fluminense · BRUniversity of Basel · CHFundação Oswaldo Cruz · BRRadford University College · GHUniversity of Ghana · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis B virus (HBV) infections account for approximately 780,000 deaths per year, most of which occur in the developing world. Co-infection with HBV and hepatitis delta virus (HDV) may lead to the most severe form of viral hepatitis. In Ghana, knowledge on the prevalence of HBV and HDV in the general population is scanty and the few genetic analyses of the prevailing HBV genotypes are dating back more than a decade. In the present study, 1,323 serum samples from individuals living in a rural area (Offin river valley) of Ghana were analyzed for the presence of the hepatitis B surface antigen (HBsAg). Positive sera were subsequently tested for the presence of anti-HDV antibodies. A total of 107 (8%) sera were HBsAg positive with an 8.4% prevalence of anti-HDV antibodies among the HBsAg positives. Phylogenetic analysis based on HBV pre-S/S sequences, attributed all 52 typable samples to genotype E. All belonged to serotype ayw4. While 19 sequences clustered with those from a number of African countries, the other 33 formed a separate cluster distinguished by an intergroup mean distance of 1.5% from the pan-African HBV/E cluster. Successful implementation of HBV vaccination in the region was reflected by the low HBsAg carrier rate of 1.8% among children ≤11 years.

Indexed as

Genetic VariationAdolescentAdultAgedAged, 80 and overCarrier StateChildChild, PreschoolDNA, ViralFemaleGhanaHepatitis AntibodiesHepatitis BHepatitis B Surface AntigensHepatitis B virusHumansDNA, ViralHepatitis AntibodiesHepatitis B Surface Antigens

Identifiers

PMID27271290
PMCPMC4894622
OpenAlexW2409449564

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.