ArticleScientific reports2016
Forced rather than voluntary exercise entrains peripheral clocks via a corticosterone/noradrenaline increase in PER2::LUC mice.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06601660 (Effect of Combined Physical Training At Different Times of the Day on Muscle and Adipose Tissue Remodeling, Metabolism and Physical Performance in Female Mice and Women with Obesity), which is not on this map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Combined Physical Training At Different Times of the Day on Muscle and Adipose Tissue Remodeling, Metabolism and Physical Performance in Female Mice and Women with Obesity
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review.Frontiers in endocrinology · 2021Pooled it
- Trial
- Investigating circadian clock gene expression in human tendon biopsies from acute exercise and immobilization studies.European journal of applied physiology · 2019Trial
- Chronotype and social jetlag influence human circadian clock gene expression.Scientific reports · 2018Trial
- Circadian rhythm: The hidden "puppet master" behind musculoskeletal disorders.Journal of orthopaedic translation · 2026Review
- Morning endurance training induces superior performance adaptations compared with afternoon training in mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Exercise and neural circuit stability in early Alzheimer's disease: evidence across memory, executive, cholinergic, and circadian systems.Frontiers in aging neuroscience · 2026Review
- Transcriptomic Analysis of High-Intensity Interval Training in High-Fat-Diet-Induced Spontaneous Hypertensive Rats' Brains.International journal of molecular sciences · 2025Article
- Circadian clock and its effect on aging and lifespan.Biogerontology · 2025Review
- Circadian Rhythm and Muscle Function.Advances in experimental medicine and biology · 2025Review
- Clockwork conditioning: Aligning the skeletal muscle clock with time-of-day exercise for cardiometabolic health.Journal of molecular and cellular cardiology · 2025Review
- Synergy between time-restricted feeding and time-restricted running is necessary to shift the muscle clock in male wistar rats.Neurobiology of sleep and circadian rhythms · 2024Article
- A coupled model between circadian, cell-cycle, and redox rhythms reveals their regulation of oxidative stress.Scientific reports · 2024Article
- Circadian Regulation of Cardiac Arrhythmias and Electrophysiology.Circulation research · 2024Review
- Circadian rhythm of intraocular pressure.The journal of physiological sciences : JPS · 2024Review
- Effects of time-restricted exercise on activity rhythms and exercise-induced adaptations in the heart.Scientific reports · 2024Article
- Daytime sleepiness in Chinese professional, semi professional and students soccer players in the Shanghai lockdown.BMC sports science, medicine & rehabilitation · 2023Article
- Enhancing circadian rhythms-the circadian MEGA bundle as novel approach to treat critical illness.Annals of translational medicine · 2023Review
- Review
- Chrono-exercise: Time-of-day-dependent physiological responses to exercise.Sports medicine and health science · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise during the inactive period can entrain locomotor activity and peripheral circadian clock rhythm in mice; however, mechanisms underlying this entrainment are yet to be elucidated. Here, we showed that the bioluminescence rhythm of peripheral clocks in PER2::LUC mice was strongly entrained by forced treadmill and forced wheel-running exercise rather than by voluntary wheel-running exercise at middle time during the inactivity period. Exercise-induced entrainment was accompanied by increased levels of serum corticosterone and norepinephrine in peripheral tissues, similar to the physical stress-induced response. Adrenalectomy with norepinephrine receptor blockers completely blocked the treadmill exercise-induced entrainment. The entrainment of the peripheral clock by exercise is independent of the suprachiasmatic nucleus clock, the main oscillator in mammals. The present results suggest that the response of forced exercise, but not voluntary exercise, may be similar to that of stress, and possesses the entrainment ability of peripheral clocks through the activation of the adrenal gland and the sympathetic nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.