ArticleNature methods2016
Quantitative detection of low-abundance somatic structural variants in normal cells by high-throughput sequencing.
Article in Nature methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A simple method to efficiently generate structural variation in plants.PLoS genetics · 2025Article
- Somatic mutation burden in relation to aging and functional life span: implications for cellular reprogramming and rejuvenation.Current opinion in genetics & development · 2023Review
- Chromosome instability and aneuploidy in the mammalian brain.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Review
- Single-molecule, quantitative detection of low-abundance somatic mutations by high-throughput sequencing.Science advances · 2022Article
- R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements.PLoS genetics · 2021Article
- FOXO3a acts to suppress DNA double-strand break-induced mutations.Aging cell · 2020Article
- Ultra-High-Frequency Reprogramming of Individual Long-Term Hematopoietic Stem Cells Yields Low Somatic Variant Induced Pluripotent Stem Cells.Cell reports · 2019Article
- Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging.Annual review of genetics · 2018Review
- Bleomycin-induced genome structural variations in normal, non-tumor cells.Scientific reports · 2018Article
- Do DNA Double-Strand Breaks Drive Aging?Molecular cell · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The detection and quantification of low-abundance somatic DNA mutations by high-throughput sequencing is challenging because of the difficulty of distinguishing errors from true mutations. There are several approaches available for analyzing somatic point mutations and small insertions or deletions, but an accurate genome-wide assessment of somatic structural variants (somSVs) in bulk DNA is still not possible. Here we present Structural Variant Search (SVS), a method to accurately detect rare somSVs by low-coverage sequencing. We demonstrate direct quantitative assessment of elevated somSV frequencies induced by known clastogenic compounds in human primary cells.
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Registered trials
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