ArticleJournal of pathology and translational medicine2016
Detection of Tumor Multifocality Is Important for Prediction of Tumor Recurrence in Papillary Thyroid Microcarcinoma: A Retrospective Study and Meta-Analysis.
Article in Journal of pathology and translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Total thyroidectomy may be more reasonable as initial surgery in unilateral multifocal papillary thyroid microcarcinoma: a single-center experience.World journal of surgical oncology · 2017Trial
- Clinical Impact of Multifocality and Bilaterality on Lymph Node Metastasis in Papillary Thyroid Microcarcinoma.Diagnostics (Basel, Switzerland) · 2026Article
- Risk Stratification in Papillary Thyroid Microcarcinoma: Clinical Features Predicting Multifocality, Lymph Node Metastasis, and Recurrence - A Retrospective Cohort Study.Cancer management and research · 2026Article
- The value of total tumor diameter in unilateral multifocal papillary thyroid carcinoma: a propensity score matching analysis.Frontiers in endocrinology · 2023Article
- Total tumor diameter is a better indicator of multifocal papillary thyroid microcarcinoma: A propensity score matching analysis.Frontiers in endocrinology · 2022Article
- The relationship between lipotoxicity and risk of extrathyroidal extension in papillary thyroid microcarcinoma.Endocrine · 2021Article
- Multifocality and Progression of Papillary Thyroid Microcarcinoma During Active Surveillance.World journal of surgery · 2021Article
- Correlation of ThyroSeq Results with Surgical Histopathology in Cytologically Indeterminate Thyroid Nodules.Endocrine pathology · 2020Article
- Multifocal papillary thyroid cancer in children and adolescents: 12-year experience in a single center.Gland surgery · 2019Article
- Analysis of Malignant Thyroid Neoplasms with a Striking Rise of Papillary Microcarcinoma in an Endemic Goiter Region.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2019Article
- The role of prophylactic central compartment lymph node dissection in elderly patients with differentiated thyroid cancer: a multicentric study.BMC surgery · 2019Article
- Cervical Lymph Node Metastases of Papillary Thyroid Carcinoma, in the Central and Lateral Compartments, in Children and Adolescents: Predictive Factors.World journal of surgery · 2018Article
- Active Surveillance for Papillary Thyroid Microcarcinoma: Challenges and Prospects.Frontiers in endocrinology · 2018Review
- Radioactive Iodine Ablation Decrease Recurrences in Papillary Thyroid Microcarcinoma with Lateral Lymph Node Metastasis in Chinese Patients.World journal of surgery · 2017Article
- Article
- The Prognostic Value of Tumor Multifocality in Clinical Outcomes of Papillary Thyroid Cancer.The Journal of clinical endocrinology and metabolism · 2017Article
- The first postoperative-stimulated serum thyroglobulin is a prognostic factor for thyroid microcarcinomas.Brazilian journal of otorhinolaryngologyArticle
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinicopathological characteristics and conclusive treatment modality for multifocal papillary thyroid microcarcinoma (mPTMC) have not been fully established.
methodsA retrospective study, systematic review, and meta-analysis were conducted to elucidate the clinicopathological significance of mPTMC. We investigated the multiplicity of 383 classical papillary thyroid microcarcinomas (PTMCs) and the clinicopathological significance of incidental mPTMCs. Correlation between tumor recurrence and multifocality in PTMCs was evaluated through a systematic review and meta-analysis.
resultsTumor multifocality was identified in 103 of 383 PTMCs (26.9%). On linear regression analysis, primary tumor diameter was significantly correlated with tumor number (R(2)=0.014, p=.021) and supplemental tumor diameter (R(2)=0.117, p=.023). Of 103 mPTMCs, 61 (59.2%) were non-incidental, with tumor detected on preoperative ultrasonography, and 42 (40.8%) were diagnosed (incidental mPTMCs) on pathological examination. Lymph node metastasis and higher tumor stage were significantly correlated with tumor multifocality. However, there was no difference in nodal metastasis or tumor stage between incidental and non-incidental mPTMCs. On meta-analysis, tumor multifocality was significantly correlated with tumor recurrence in PTMCs (odds ratio, 2.002; 95% confidence interval, 1.475 to 2.719, p<.001).
conclusionsOur results show that tumor multifocality in PTMC, regardless of manner of detection, is significantly correlated with aggressive tumor behavior.
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