ArticleScientific reports2016
A 2-Cys peroxiredoxin in response to oxidative stress in the pine wood nematode, Bursaphelenchus xylophilus.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Novel SNPs Linked to Blast Resistance Genes Identified in Pearl Millet Through Genome-Wide Association Models.International journal of molecular sciences · 2024Article
- Insights into the plant response to nematode invasion and modulation of host defense by plant parasitic nematode.Frontiers in microbiology · 2024Review
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- Occurrence, Density, and Transcriptomic Response of the Leafhopper Erythroneura sudra (Hemiptera: Cicadellidae) When Confronted With Different Fruit Tree Species.Journal of insect science (Online) · 2022Article
- Article
- Molecular variation among virulent and avirulent strains of the quarantine nematode Bursaphelenchus xylophilus.Molecular genetics and genomics : MGG · 2021Article
- A Complex Proteomic Response of the Parasitic Nematode Anisakis simplex s.s. to Escherichia coliLipopolysaccharide.Molecular & cellular proteomics : MCP · 2021Article
- Cytochrome P450 metabolism mediates low-temperature resistance in pinewood nematode.FEBS open bio · 2020Article
- Article
- Transcriptome-Based Analysis Reveals a Crucial Role ofInternational journal of molecular sciences · 2019Article
- Enhancement of oxidative stress contributes to increased pathogenicity of the invasive pine wood nematode.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Nematicidal and insecticidal activities of halogenated indoles.Scientific reports · 2019Article
- Plant-parasitic nematodes: towards understanding molecular players in stress responses.Annals of botany · 2017Review
- Bursaphelenchus xylophilus and B. mucronatus secretomes: a comparative proteomic analysis.Scientific reports · 2016Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pine wood nematode, Bursaphelenchus xylophilus, is the causal agent of pine wilt disease that has devastated pine forests in Asia. Parasitic nematodes are known to have evolved antioxidant stress responses that defend against host plant defenses. In this study, the infestation of whitebark pine, Pinus bungean, with B. xylophilus led to a significant increase in plant hydrogen peroxide (H2O2) and salicylic acid levels. Correspondingly, the expression of an antioxidative enzyme, 2-Cysteine peroxiredoxin (BxPrx), was elevated in B. xylophilus following the H2O2 treatments. Recombinant BxPrx, a thermal stabile and pH tolerant enzyme, exhibited high level of antioxidant activity against H2O2, suggesting that it is capable of protecting cells from free radical attacks. Immunohistochemical localization study showed that BxPrx was broadly expressed across different tissues and could be secreted outside the nematode. Finally, the number of BxPrx homologs in both dauer-like and fungi-feeding B. xylophilus were comparable based on bioinformatics analysis of existing EST libraries, indicating a potential role of BxPrx in both propagative and dispersal nematodes. These combined results suggest that BxPrx is a key genetic factor facilitating the infestation and distribution of B. xylophilus within pine hosts, and consequently the spread of pine wilt disease.
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