Evidence map›Paper›PMID 27270892›Full record

ReviewThe Journal of experimental medicine2016

Live cell imaging to understand monocyte, macrophage, and dendritic cell function in atherosclerosis.

Sara McArdle, Zbigniew Mikulski, Klaus Ley

Abstract readReview
In one paragraph

Review in The Journal of experimental medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. New insights into macrophage subsets in atherosclerosis.Journal of molecular medicine (Berlin, Germany) · 2022
    Review
  8. Review
  9. Review
  10. Review
  11. Visualization of integrin molecules by fluorescence imaging and techniques.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2021
    Article
  12. Review
  13. Hematopoiesis and Cardiovascular Disease.Circulation research · 2020
    Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Smooth Muscle Cell Phenotypic Diversity.Arteriosclerosis, thrombosis, and vascular biology · 2019
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Sara McArdleDivision of Inflammation Biology and Microscopy Core, La Jolla Institute of Allergy and Immunology, La Jolla, CA 92037.
Zbigniew MikulskiDivision of Inflammation Biology and Microscopy Core, La Jolla Institute of Allergy and Immunology, La Jolla, CA 92037.
Klaus LeyDivision of Inflammation Biology and Microscopy Core, La Jolla Institute of Allergy and Immunology, La Jolla, CA 92037 klaus@lji.org.

Funding

Integrative Bioengineering of Heart, Vessels, and BloodT32HL105373 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, INTAGLIETTA, MARCOS · 2010 to 2019
$3.6M
Myeloid cell interactions with T cells in atherosclerosisR01HL115232 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2012 to 2018
$3.2M
NHLBI NIH HHS R01 HL115232NHLBI NIH HHS T32 HL105373
6 · The paper itself

Abstract

Intravital imaging is an invaluable tool for understanding the function of cells in healthy and diseased tissues. It provides a window into dynamic processes that cannot be studied by other techniques. This review will cover the benefits and limitations of various techniques for labeling and imaging myeloid cells, with a special focus on imaging cells in atherosclerotic arteries. Although intravital imaging is a powerful tool for understanding cell function, it alone does not provide a complete picture of the cell. Other techniques, such as flow cytometry and transcriptomics, must be combined with intravital imaging to fully understand a cell's phenotype, lineage, and function.

Indexed as

AnimalsAtherosclerosisDendritic CellsHumansIntravital MicroscopyMacrophagesMonocytes

Identifiers

PMID27270892
PMCPMC4925021

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.