Evidence map›Paper›PMID 27270699›Full record

ReviewGenetics2016

Tetrahymena as a Unicellular Model Eukaryote: Genetic and Genomic Tools.

Marisa D Ruehle, Eduardo Orias, Chad G Pearson

Open access · bronzeAbstract readReview
In one paragraph

Review in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 122 citations in OpenAlex.

  1. Molecular biology of the cell · 2026
    Article
  2. Article
  3. bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Cystathionine β-synthase TtCbs1 fromApplied and environmental microbiology · 2025
    Article
  6. Generalizing the central dogma as a cross-hierarchical principle of biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  7. Article
  8. Article
  9. mBio · 2025
    Article
  10. Article
  11. Bacterivorous CiliateAntibiotics (Basel, Switzerland) · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Frontiers in genetics · 2025
    Article
  18. Article
  19. Review
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Marisa D RuehleDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045 Marisa.Ruehle@ucdenver.edu.
Eduardo OriasDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, California 93106.
Chad G PearsonDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045.
University of Colorado Anschutz Medical Campus · USUniversity of California, Santa Barbara · US

Funding

Mechanisms of centriole assembly and stabilityR01GM099820 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI PEARSON, CHAD G · 2012 to 2020
$2.9M
NIGMS NIH HHS R01 GM099820
6 · The paper itself

Abstract

Tetrahymena thermophila is a ciliate model organism whose study has led to important discoveries and insights into both conserved and divergent biological processes. In this review, we describe the tools for the use of Tetrahymena as a model eukaryote, including an overview of its life cycle, orientation to its evolutionary roots, and methodological approaches to forward and reverse genetics. Recent genomic tools have expanded Tetrahymena's utility as a genetic model system. With the unique advantages that Tetrahymena provide, we argue that it will continue to be a model organism of choice.

Indexed as

Genes, ProtozoanGenetic TechniquesTetrahymenaamitosisciliatesgeneticsmodel organismsomatic polyploidyTetrahymena thermophila

Identifiers

PMID27270699
PMCPMC4896184
OpenAlexW2411754504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.