ArticleOncotarget2016
The prognostic value of lymph nodes count on survival of patients with node-negative gastric cancer.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Review
- Indications for adjuvant chemotherapy in patients with pT1N1M0 gastric cancer: a single-center experience.Journal of cancer research and clinical oncology · 2021Article
- The impact of negative lymph nodes in the survival outcomes of pN+ patients following radical gastrectomy: the inverse lymph node ratio as a better score to study negative lymph nodes.Updates in surgery · 2020Article
- Prognostic value of total retrieved lymph nodes on the survival of patients with advanced gastric cancer.Journal of the Chinese Medical Association : JCMA · 2020Article
- Impact of the number of examined lymph nodes on stage migration in node-negative gastric cancer patients: a Chinese multi-institutional analysis with propensity score matching.Annals of translational medicine · 2020Article
- Prognostic Value of the Number of Lymph Nodes Examined in Patients with Node-Negative Gastric Cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019Article
- Nodal staging score and adequacy of nodal staging.OncoTargets and therapy · 2019Article
- Effect of lymph nodes count in node-positive gastric cancer.Journal of Cancer · 2019Article
- Prognostic value of lymph nodes count on survival of patients with distal cholangiocarcinomas.World journal of gastroenterology · 2018Article
- Greater Lymph Node Retrieval Improves Survival in Node-Negative Resected Gastric Cancer in the United States.Journal of gastric cancer · 2017Article
- Negative lymph node count is a significant prognostic factor in patient with stage IV gastric cancer after palliative gastrectomy.Oncotarget · 2017Article
- Association of Lymph Node Count and Overall Survival in Node-Negative Endometrial Cancers.JCO clinical cancer informatics · 2017Article
- Development and Validation of a Nomogram to Predict the Benefit of Adjuvant Radiotherapy for Patients with Resected Gastric Cancer.Journal of Cancer · 2017Article
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Authors and funding
4 authors.
Funding
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Abstract
The retrieved lymph node (LN) count has been validated as a prognostic factor in various cancers. However, the interaction between LN counts and patients' prognosis in gastric cancer with negative-LN metastasis is not fully studied. Surveillance, Epidemiology, and End Results Program (SEER)-registered gastric cancer patients were used for analysis in this study. Patients operated on for gastric cancer at N0 stage between 2004 and 2012 were identified from the SEER database. The association between the LN counts and survival was assessed using the Cox proportional hazards model. Patients were stratified into 1-4, 5-13, and > 13 subgroups according to LN count cut-off values determined by X-tile program, with the 5-year cause specific survival (CSS) rate of 64.8%, 72.5%, and 79.4%, respectively. LN count was also validated as an independently prognostic factor in multivariate Cox analysis (P < 0.001). In addition, nomograms including LN counts on CSS were established according to all significant factors, and the c-index was 0.703 (95% CI: 0.672-0.734). Further study indicated that patients with no LN metastasis had a decreased risk of death for each patient with LN examined up to approximately 14 LNs. Collectively, our study firmly demonstrated that the number of the retrieved LNs count was an independent prognostic factor for gastric cancer with no LN metastasis. The higher the LN count, the better the survival would be; the best CSS was observed on the LN count more than 14.
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