Evidence map›Paper›PMID 27270338›Full record

ArticleAsian journal of andrology

Regeneration of rat corpora cavernosa tissue by transplantation of CD133

Shogo Inoue, Katsutoshi Miyamoto, Shunsuke Shinmei, Koichi Shoji, Jun Teishima, Kazuhiro Sentani, Wataru Yasui, Akio Matsubara

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shogo InoueDepartment of Urology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan.
Katsutoshi MiyamotoDepartment of Urology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan.
Shunsuke ShinmeiDepartment of Urology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan.
Koichi ShojiDepartment of Urology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan.
Jun TeishimaDepartment of Urology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan.
Kazuhiro SentaniDepartment of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan.
Wataru YasuiDepartment of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan.
Akio MatsubaraDepartment of Urology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan.
Hiroshima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective is to develop an easier technique for regenerating corpora cavernosa tissue through transplantation of human bone marrow-derived CD133 + cells into a rat corpora cavernosa defect model. We excised 2 mm × 2 mm squares of the right corpora cavernosa of twenty-three 8-week-old male nude rats. Alginate gel sponge sheets supplemented with 1 × 10 4 CD133 + cells were then placed over the excised area of nine rats. Functional and histological evaluations were carried out 8 weeks later. The mean intracavernous pressure/mean arterial pressure ratio for the nine rats (0.34258 ± 0.0831) was significantly higher than that for eight rats with only the excision (0.0580 ± 0.0831, P = 0.0238) and similar to that for five rats for which the penis was exposed, and there was no excision (0.37228 ± 0.1051, P = 0.8266). Immunohistochemical analysis revealed that the nine fully treated rats had venous sinus-like structures and quantitative reverse transcription polymerase chain reaction analysis of extracts from their alginate gel sponge sheets revealed that the amounts of mRNA encoding the nerve growth factor (NGF), and vascular endothelial growth factor (VEGF) were significantly higher than those for rats treated with alginate gel sheets without cell supplementation (NGF: P = 0.0309; VEGF: P < 0.0001). These findings show that transplantation of CD133 + cells accelerates functional and histological recovery in the corpora cavernosa defect model.

Indexed as

Penile ErectionRegenerationAbsorbable ImplantsAC133 AntigenActinsAlginatesAnimalsBone Marrow CellsBone Marrow TransplantationGelsGlucuronic AcidHexuronic AcidsHumansMaleNerve Growth FactorPenisAC133 AntigenActa2 protein, ratActinsAlginatesGelsGlucuronic AcidHexuronic AcidsNerve Growth FactorPROM1 protein, humanVascular Endothelial Growth Factor Avascular endothelial growth factor A, rat

Identifiers

PMID27270338
PMCPMC5312219
OpenAlexW2318224127

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.