ArticleScientific reports2016
Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 71 citations in OpenAlex.
- Phytochemical Analysis and Biological Activities of Essential Oils from Leaves and Stems ofMolecules (Basel, Switzerland) · 2026Article
- Deciphering Bax Dynamics: Regulation, Retrotranslocation, and Mitochondrial Interplay in the Commitment to Apoptosis: A Narrative Review.Health science reports · 2026Article
- Recent Advances in Lemongrass Essential Oil: Food Safety, Preservation, and Bioactivity in Food Systems.Comprehensive reviews in food science and food safety · 2026Review
- Data mining of PubChem bioassay records reveals diverse OXPHOS inhibitory chemotypes as potential therapeutic agents against ovarian cancer.Journal of cheminformatics · 2024Article
- Enhancing Selectivity and Inhibitory Effects of Chemotherapy Drugs Against Myelogenous Leukemia Cells withInternational journal of molecular sciences · 2024Article
- Insights into chemistry, extraction and industrial application of lemon grass essential oil -A review of recent advances.Food chemistry: X · 2024Review
- Fabrication of novel nanofiber composed of gelatin/alginate with zirconium oxide NPs regulate orthodontic progression of cartilage degeneration on Wnt/β-catenin signaling axis in MC3T3-E1 cells.Regenerative therapy · 2024Article
- Oxidative phosphorylation inhibitors inhibit proliferation of endometriosis cells.Reproduction (Cambridge, England) · 2023Article
- Atovaquone: An Inhibitor of Oxidative Phosphorylation as Studied in Gynecologic Cancers.Cancers · 2022Article
- Uncovering the Industrial Potentials of Lemongrass Essential Oil as a Food Preservative: A Review.Antioxidants (Basel, Switzerland) · 2022Review
- Targeting Apoptosis in Cancer.Current oncology reports · 2022Review
- Monocarboxylate Transporter 4 in Cancer-Associated Fibroblasts Is a Driver of Aggressiveness in Aerodigestive Tract Cancers.Frontiers in oncology · 2022Article
- Lemongrass Essential Oil Components with Antimicrobial and Anticancer Activities.Antioxidants (Basel, Switzerland) · 2021Review
- Phytochemical Analysis and In Vitro Cytotoxic Activity against Colorectal Adenocarcinoma Cells ofPlants (Basel, Switzerland) · 2021Article
- Docosahexaenoic Acid Inhibits Cell Proliferation through a Suppression of c-Myc Protein in Pancreatic Ductal Adenocarcinoma Cells.Antioxidants (Basel, Switzerland) · 2021Article
- Insecticidal Activity of Lemongrass Essential Oil as an Eco-Friendly Agent against the Black CutwormInsects · 2021Article
- Anticarcinogenic Effects of Odorant Substances Citral, Citrathal R and Cyclovertal on Breast Cancer in vitro.Breast cancer (Dove Medical Press) · 2021Article
- Hypothermic Effect of Acute Citral Treatment during LPS-induced Systemic Inflammation in Obese Mice: Reduction of Serum TNF-α and Leptin Levels.Biomolecules · 2020Article
- Involvement of CHOP in activin A‑induced myeloma NS‑1 cell apoptosis.Oncology reports · 2019Article
- Soluble guanylyl cyclase α1 subunit is a key mediator of proliferation, survival, and migration in ECC-1 and HeLa cell lines.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
The monoterpenoid, citral, when delivered through PEG-b-PCL nanoparticles inhibits in vivo growth of 4T1 breast tumors. Here, we show that citral inhibits proliferation of multiple human cancer cell lines. In p53 expressing ECC-1 and OVCAR-3 but not in p53-deficient SKOV-3 cells, citral induces G1/S cell cycle arrest and apoptosis as determined by Annexin V staining and increased cleaved caspase3 and Bax and decreased Bcl-2. In SKOV-3 cells, citral induces the ER stress markers CHOP, GADD45, EDEM, ATF4, Hsp90, ATG5, and phospho-eIF2α. The molecular chaperone 4-phenylbutyric acid attenuates citral activity in SKOV-3 but not in ECC-1 and OVCAR-3 cells. In p53-expressing cells, citral increases phosphorylation of serine-15 of p53. Activation of p53 increases Bax, PUMA, and NOXA expression. Inhibition of p53 by pifithrin-α, attenuates citral-mediated apoptosis. Citral increases intracellular oxygen radicals and this leads to activation of p53. Inhibition of glutathione synthesis by L-buthionine sulfoxamine increases potency of citral. Pretreatment with N-acetylcysteine decreases phosphorylation of p53 in citral-treated ECC-1 and OVCAR-3. These results define a p53-dependent, and in the absence of p53, ER stress-dependent mode of action of citral. This study indicates that citral in PEG-b-PCL nanoparticle formulation should be considered for treatment of breast and other tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.