ArticleScientific reports2016
Programmable DNA Nanosystem for Molecular Interrogation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Recent Advances in DNA Origami-Enabled Optical Biosensors for Multi-Scenario Application.Nanomaterials (Basel, Switzerland) · 2024Review
- In vitro transcription of self-assembling DNA nanoparticles.Scientific reports · 2023Article
- Functionalizing DNA origami to investigate and interact with biological systems.Nature reviews. Materials · 2023Article
- A modular spring-loaded actuator for mechanical activation of membrane proteins.Nature communications · 2022Article
- DNA Origami as Emerging Technology for the Engineering of Fluorescent and Plasmonic-Based Biosensors.Materials (Basel, Switzerland) · 2020Review
- The Growing Development of DNA Nanostructures for Potential Healthcare-Related Applications.Advanced healthcare materials · 2019Review
- Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe a self-assembling DNA-based nanosystem for interrogating molecular interactions. The nanosystem contains a rigid supporting dumbbell-shaped frame, a cylindrical central core, and a mobile ring that is coaxial with the core. Motion of the ring is influenced by several control elements whose force-generating capability is based on the transition of single-stranded DNA to double-stranded DNA. These forces can be directed to act in opposition to adhesive forces between the ring and the frame thereby providing a mechanism for molecular detection and interrogation at the ring-frame interface. As proof of principle we use this system to evaluate base stacking adhesion and demonstrate detection of a soluble nucleic acid viral genome mimic.
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Registered trials
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