ArticleNano letters2016
Single-Molecule Reaction Chemistry in Patterned Nanowells.
Article in Nano letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Decoding information stored in DNAs through single-molecule electrical detection platforms.Innovation (Cambridge (Mass.)) · 2025Review
- RNA adapts its flexibility to efficiently fold and resist unfolding.Nucleic acids research · 2025Article
- Healing Defects in Armchair Graphene Nanoribbons for Enhanced Charge Transport.ACS applied nano materials · 2025Article
- Technologies for investigating single-molecule chemical reactions.National science review · 2024Review
- Carbon-nanotube field-effect transistors for resolving single-molecule aptamer-ligand binding kinetics.Nature nanotechnology · 2024Article
- Characterizing the Conformational Free-Energy Landscape of RNA Stem-Loops Using Single-Molecule Field-Effect Transistors.Journal of the American Chemical Society · 2023Article
- Inferring the shape of data: a probabilistic framework for analysing experiments in the natural sciences.Proceedings. Mathematical, physical, and engineering sciences · 2022Article
- A Critical Review on the Sensing, Control, and Manipulation of Single Molecules on Optofluidic Devices.Micromachines · 2022Review
- Charge Transport in and Electroluminescence from spACS nano · 2021Article
- Understanding and Mapping Sensitivity in MoSACS nano · 2020Article
- The Emergence of Insect Odorant Receptor-Based Biosensors.Biosensors · 2020Review
- Bayesian-Estimated Hierarchical HMMs Enable Robust Analysis of Single-Molecule Kinetic Heterogeneity.Biophysical journal · 2019Article
- Using Microfluidics and Imaging SAMDI-MS To Characterize Reaction Kinetics.ACS central science · 2019Article
- Electrically Controllable Single-Point Covalent Functionalization of Spin-Cast Carbon-Nanotube Field-Effect Transistor Arrays.ACS nano · 2018Article
- Direct observation of single-molecule hydrogen-bond dynamics with single-bond resolution.Nature communications · 2018Article
- Direct single-molecule dynamic detection of chemical reactions.Science advances · 2018Article
- Electrostatic melting in a single-molecule field-effect transistor with applications in genomic identification.Nature communications · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
A new approach to synthetic chemistry is performed in ultraminiaturized, nanofabricated reaction chambers. Using lithographically defined nanowells, we achieve single-point covalent chemistry on hundreds of individual carbon nanotube transistors, providing robust statistics and unprecedented spatial resolution in adduct position. Each device acts as a sensor to detect, in real-time and through quantized changes in conductance, single-point functionalization of the nanotube as well as consecutive chemical reactions, molecular interactions, and molecular conformational changes occurring on the resulting single-molecule probe. In particular, we use a set of sequential bioconjugation reactions to tether a single-strand of DNA to the device and record its repeated, reversible folding into a G-quadruplex structure. The stable covalent tether allows us to measure the same molecule in different solutions, revealing the characteristic increased stability of the G-quadruplex structure in the presence of potassium ions (K(+)) versus sodium ions (Na(+)). Nanowell-confined reaction chemistry on carbon nanotube devices offers a versatile method to isolate and monitor individual molecules during successive chemical reactions over an extended period of time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.