ArticleJournal of clinical and experimental neuropsychology2016
Hepatitis C virus antibody titers associated with cognitive dysfunction in an asymptomatic community-based sample.
Article in Journal of clinical and experimental neuropsychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gender differences in prevalence of hepatitis C virus infection in Egypt: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample.Schizophrenia (Heidelberg, Germany) · 2025Article
- Neurocognitive functioning during adolescence: Spanish validation of the Penn Computerized Neurocognitive Battery.International journal of methods in psychiatric research · 2024Article
- Hepatitis C Virus (HCV) Infection and Neurocognitive Impairment in Subjects with Mild Liver Disease.Journal of clinical medicine · 2023Article
- Different profiles of neurocognitive impairment in patients with hepatitis B and C virus infections.Scientific reports · 2022Article
- The Many Difficulties and Subtleties in the Cognitive Assessment of Chronic Hepatitis C Infection.International journal of hepatology · 2020Review
- An Overview of the Most Significant Zoonotic Viral Pathogens Transmitted from Animal to Human in Saudi Arabia.Pathogens (Basel, Switzerland) · 2019Review
- Chronic Tobacco-Smoking on Psychopathological Symptoms, Impulsivity and Cognitive Deficits in HIV-Infected Individuals.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2017Article
- A Comprehensive Review of Common Bacterial, Parasitic and Viral Zoonoses at the Human-Animal Interface in Egypt.Pathogens (Basel, Switzerland) · 2017Review
- Cognitive decline assessment in speakers of understudied languages.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundHepatitis C virus (HCV) infection is associated with cognitive dysfunction in clinic-based studies. The risk could be attributed to factors such as antiviral medications, substance abuse, or coincidental infection.
aimThe aim was to evaluate cognitive function in relation to HCV antibody titers in a community-based sample of asymptomatic individuals at low risk for substance abuse.
methodAdults were ascertained from a community in Mansoura, Egypt, where HCV is endemic (n = 258). Cognitive performance was evaluated using the Arabic version of the Penn Computerized Neurocognitive Battery. Substance abuse and psychopathology were also assessed. Antibodies to HCV and Toxoplasma gondii (TOX), a common protozoan that can affect cognition, were estimated using serological IgG assays.
resultsThe prevalence of HCV and TOX infection was 17.6% and 52.9%, respectively. HCV antibody titers were significantly associated with worse function in four cognitive tests for accuracy and three tests for speed, after adjusting for covariates (p < .05, beta coefficients, 2.1-3.2). TOX antibody titers were associated with impaired accuracy in one test.
conclusionsThe association between HCV antibody titers and cognitive impairment is not mediated by antiviral treatment or substance abuse in this sample. Whether HCV has a causal role in the cognitive dysfunction should be investigated.
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