Evidence map›Paper›PMID 27269374›Full record

ReviewSeminars in cell & developmental biology2017

Computational models of airway branching morphogenesis.

Victor D Varner, Celeste M Nelson

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Multi-scale models of lung fibrosis.Matrix biology : journal of the International Society for Matrix Biology · 2020
    Review
  4. Review
  5. Article
  6. Review
  7. Spontaneous calcium activity in metanephric mesenchymal cells regulates branching morphogenesis in the embryonic kidney.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  8. Review
  9. A review of inflammatory mechanism in airway diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019
    Review
  10. Cellular mechanisms of morphogenesis.Seminars in cell & developmental biology · 2017
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Victor D VarnerDepartment of Chemical & Biological Engineering, Princeton University, Princeton, NJ 08544, United States.
Celeste M NelsonDepartment of Chemical & Biological Engineering, Princeton University, Princeton, NJ 08544, United States; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, United States. Electronic address: celesten@princeton.edu.

Funding

Mechanical Regulation of Mesenchyme and Mammalian Lung DevelopmentR01HL120142 · NHLBI · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2014 to 2017
$1.6M
Spatial patterning of branching morphogenesisR01GM083997 · NIGMS · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2008 to 2012
$1.4M
Mechanical regulation of branching morphogenesisR21HL110335 · NHLBI · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2011 to 2012
$443k
Exogenous Fluid Forces and Branching of the Mammalian LungR21HL118532 · NHLBI · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2014 to 2015
$442k
NHLBI NIH HHS R01 HL120142NHLBI NIH HHS R21 HL110335NHLBI NIH HHS R21 HL118532NIGMS NIH HHS R01 GM083997
6 · The paper itself

Abstract

The bronchial network of the mammalian lung consists of millions of dichotomous branches arranged in a highly complex, space-filling tree. Recent computational models of branching morphogenesis in the lung have helped uncover the biological mechanisms that construct this ramified architecture. In this review, we focus on three different theoretical approaches - geometric modeling, reaction-diffusion modeling, and continuum mechanical modeling - and discuss how, taken together, these models have identified the geometric principles necessary to build an efficient bronchial network, as well as the patterning mechanisms that specify airway geometry in the developing embryo. We emphasize models that are integrated with biological experiments and suggest how recent progress in computational modeling has advanced our understanding of airway branching morphogenesis.

Indexed as

Mechanotransduction, CellularModels, BiologicalAnimalsBiomechanical PhenomenaCell Culture TechniquesComputer SimulationEmbryo, MammalianEpithelial CellsFibroblast Growth Factor 10Gene Expression RegulationHumansLungMiceModels, AnatomicMorphogenesisStress, MechanicalFgf10 protein, mouseFibroblast Growth Factor 10MechanobiologyMorphodynamicsQuantitative modelsTuring patterns

Identifiers

PMID27269374
PMCPMC5136345

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.