ArticleeLife2016
Peripheral optogenetic stimulation induces whisker movement and sensory perception in head-fixed mice.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- An elastic segment of the whisker shaft enables coding of the whisking phase via whisker torsion in rats and mice.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Imaging the large-scale and cellular response to focal traumatic brain injury in mouse neocortex.Experimental physiology · 2025Article
- Imaging the large-scale and cellular response to focal traumatic brain injury in mouse neocortex.bioRxiv : the preprint server for biology · 2024Article
- High throughput 3D gel-based neural organotypic model for cellular assays using fluorescence biosensors.Communications biology · 2022Article
- Fabrication of a Multilayer Implantable Cortical Microelectrode Probe to Improve Recording Potential.Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems · 2021Article
- Optogenetic activation of muscle contractionConnective tissue research · 2021Article
- Abnormal neocortex arealization and Sotos-like syndrome-associated behavior inScience advances · 2021Article
- Optogenetic Control of the Peripheral Nervous System.Cold Spring Harbor perspectives in medicine · 2019Review
- Optogenetic recruitment of spinal reflex pathways from large-diameter primary afferents in non-transgenic rats transduced with AAV9/Channelrhodopsin 2.The Journal of physiology · 2019Article
- Optogenetic and transcriptomic interrogation of enhanced muscle function in the paralyzed mouse whisker pad.Journal of neurophysiology · 2019Article
- Pupil Dynamics Reflect Behavioral Choice and Learning in a Go/NoGo Tactile Decision-Making Task in Mice.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We discovered that optical stimulation of the mystacial pad in Emx1-Cre;Ai27D transgenic mice induces whisker movements due to activation of ChR2 expressed in muscles controlling retraction and protraction. Using high-speed videography in anesthetized mice, we characterize the amplitude of whisker protractions evoked by varying the intensity, duration, and frequency of optogenetic stimulation. Recordings from primary somatosensory cortex (S1) in anesthetized mice indicated that optogenetic whisker pad stimulation evokes robust yet longer latency responses than mechanical whisker stimulation. In head-fixed mice trained to report optogenetic whisker pad stimulation, psychometric curves showed similar dependence on stimulus duration as evoked whisker movements and S1 activity. Furthermore, optogenetic stimulation of S1 in expert mice was sufficient to substitute for peripheral stimulation. We conclude that whisker protractions evoked by optogenetic activation of whisker pad muscles results in cortical activity and sensory perception, consistent with the coding of evoked whisker movements by reafferent sensory input.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.